Mechanisms of orofacial hyperalgesia in periapical periodontitis
| Project/Area Number |
21791868
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
SHIMIZU Kohei Nihon University, 歯学部, 助教 (10508609)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 歯痛 / 根尖病巣 / 異常疼痛 / 歯学 |
|---|
| Research Abstract |
The present findings suggest that injection of complete Freund's adjuvant (CFA) into the upper molar tooth induced mechanical allodynia in early phase and hyperalgesia in late phase. These results suggest that glial-neuronal interactions in the subnuclei interpolaris/caudalis (Vi/Vc) transition zone underlying the pain mechanisms of periapical endodontitis may play a critical role in facilitating orofacial hyperalgesia.
|
Report
(3 results)
Research Products
(15 results)
-
-
[Journal Article] Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity.2010
Author(s)
Adachi K, Shimizu K, Hu JW, Suzuki I, Sakagami H, Koshikawa N, Sessle BJ, Shinoda M, Miyamoto M, Honda K, Iwata K.
-
Journal Title
Molecular Pain 6(1)
Pages: 59-59
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
