Mechanisms of orofacial hyperalgesia in periapical periodontitis

• Project/Area Number: 21791868
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Nihon University
• Principal Investigator: SHIMIZU Kohei Nihon University, 歯学部, 助教 (10508609)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 歯痛 / 根尖病巣 / 異常疼痛 / 歯学

Research Abstract

The present findings suggest that injection of complete Freund's adjuvant (CFA) into the upper molar tooth induced mechanical allodynia in early phase and hyperalgesia in late phase. These results suggest that glial-neuronal interactions in the subnuclei interpolaris/caudalis (Vi/Vc) transition zone underlying the pain mechanisms of periapical endodontitis may play a critical role in facilitating orofacial hyperalgesia.

Research Products

• [Journal Article] 歯内療法に関連した非歯原性歯痛の一例 (2011)
  • Author(s): 清水康平、小林千明、羽鳥啓介、加籐岳詩、橋本一浩、小木會文内
  • Journal Title: 歯内療法学雑誌 32巻2号(In press)
  • NAID: 10029089697
  • Peer Reviewed
• [Journal Article] Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. (2010)
  • Author(s): Adachi K, Shimizu K, Hu JW, Suzuki I, Sakagami H, Koshikawa N, Sessle BJ, Shinoda M, Miyamoto M, Honda K, Iwata K.
  • Journal Title: Molecular Pain 6(1) Pages: 59-59
  • Peer Reviewed
• [Journal Article] Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. (2010)
  • Author(s): Adachi K
  • Journal Title: Molecular Pain Volume: 6(Open access) Pages: 59-59
  • Peer Reviewed
• [Journal Article] Microinjection of IL-1beta into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry. (2009)
  • Author(s): Shimizu K, Chai B, Lagraize SC, Wei F, Dubner R, Ren K.
  • Journal Title: Open Pain J 2 Pages: 76-83
  • Peer Reviewed
• [Journal Article] Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia : the effects of interleukin-10 and glial inhibitors. (2009)
  • Author(s): Shimizu K, Guo W, Wang H, Zou S, LaGraize SC, Iwata K, Wei F, Dubner R, Ren K.
  • Journal Title: Mol Pain 5 Pages: 75-75
  • Peer Reviewed
• [Journal Article] Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia : the effects of interleukin-to and glial inhibitors (2009)
  • Author(s): Kohei Shimizu
  • Journal Title: Molecular Pain 5
  • Peer Reviewed
• [Journal Article] Microinjection of IL-1 beta into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry (2009)
  • Author(s): Kohei Shimizu
  • Journal Title: Open Pain Journal 2 Pages: 76-83
  • Peer Reviewed
• [Presentation] 歯内療法に関連した非歯原性歯痛の一例 (2010)
  • Author(s): 清水康平
  • Organizer: 第15回日本口腔顔面痛学会
  • Place of Presentation: 九州大学医学部百年講堂(福岡県)
• [Presentation] 歯髄炎によって引き起こされる異所性疼痛異常の末梢機構 (2010)
  • Author(s): 松浦慎吾、清水康平、小木曾文内、岩田幸一
  • Organizer: 第4回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 大阪大学歯学部(大阪府)
• [Presentation] 歯髄炎によって引き起こされる異所性疼痛異常の末梢機構 (2010)
  • Author(s): 松浦慎吾、清水康平、大原絹代、原田集、岩田幸一、小木曾文内
  • Organizer: 第133回日本歯科保存学会
  • Place of Presentation: 長良川国際会議場(岐阜県)
• [Presentation] 歯髄炎によって引き起こされる異所性疼痛異常の末梢機構 (2010)
  • Author(s): 松浦慎吾
  • Organizer: 第4回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 大阪大学歯学部(大阪)
• [Presentation] 歯髄炎によって引き起こされる異所性疼痛異常の末梢機構 (2010)
  • Author(s): 松浦慎吾
  • Organizer: 第133回日本歯科保存学会
  • Place of Presentation: 長良川国際会議場(岐阜)
• [Presentation] Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cut aneous hyperalgesia : Effects of masseter and skin infiammation on NMDA receptor phosphorylation and GFAP protein levels (2009)
  • Author(s): Kohei Shimizu
  • Organizer: Society for Neuroscience
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2009-11-18
• [Presentation] 試作非接触型電磁式加振装置に関する基礎的研究 -繊維添加模擬歯根膜が測定値に及ぼす影響- (2009)
  • Author(s): 清水康平
  • Organizer: 第130回日本歯科保存学会春季学術大会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-06-12
• [Presentation] Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia : Effects of masseter and skin inflammation on NMDA receptor phosphorylation and GFAP protein levels. (2009)
  • Author(s): K.SHIMIZU, W.GUO, S.C.LAGRAIZE, F.WEI, K.IWATA, R.DUBNER, K.REN
  • Organizer: Society for Neuroscience
  • Place of Presentation: U.S.A., Chicago