Association between masticatory muscle, autonomic and cortical activity during sleep in animal model

• Project/Area Number: 21791888
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Osaka University
• Principal Investigator: KATO Takafumi Osaka University, 歯学研究科, 講師 (50367520)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 睡眠 / 咀嚼筋活動 / ブラキシズム / 律神経活動 / マイクロアローザル / ノンレム睡眠 / 大脳皮質 / 阻嚼筋活動 / 自律神経活動 / 三叉神経運動前ニューロン / α2アゴニスト / α2アビニスト

Research Abstract

Jaw muscle activities were associated with autonomic and cortical activation during NREM sleep. This association seems preserved when autonomic activity was pharmacologically suppressed. Cortical areas related to jaw motor control projected to the brainstem neurons such as trigeminal premotoneurons. Arousal activity such as c ortical and autonomic activations can be related to the genesis of jaw motor activity that might be further modulated under the influences of cortical descending inputs during NREM sleep.

Research Products

• [Journal Article] Alteration of masticatory muscle EMG activities during chewing after a reversible bite-raising in guinea pigs. (2011)
  • Author(s): Kanayama H, Masuda Y, Adachi T, Arai Y, Kato T, Morimoto T
  • Journal Title: Archives of Oral Biology in press
  • Peer Reviewed
• [Journal Article] Alteration of masticatory muscle EMG activities during chewing after a reversible bite-raising in guinea pigs. (2011)
  • Author(s): Kanayama H, et al.
  • Journal Title: Archives of Oral Biology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Heterogeneous activity level of jaw-closing and -opening muscles and its association with arousal levels during sleep in the guinea pig. (2010)
  • Author(s): Kato T, Masuda Y, Kanayama H, Nakamura N, Yoshida A, Morimoto T.
  • Journal Title: American Journal of Physiology : Regulatory, Integrative and Comparative Physiology 298
  • Peer Reviewed
• [Journal Article] Sleep bruxism : a sleep related movement disorder. (2010)
  • Author(s): Kato T, Lavigne GJ.
  • Journal Title: Sleep Medicine Clinics 5 Pages: 9-35
  • Peer Reviewed
• [Journal Article] Temporal alteration of chewing jaw movements after a reversible bite-raising in guinea pigs. (2010)
  • Author(s): Kanayama H, Masuda Y, Adachi T, Arai Y, Kato T, Morimoto T.
  • Journal Title: Archives of Oral Biology 55 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Sleep bruxism : a sleep related movement disorder. (2010)
  • Author(s): Kato T, et al.
  • Journal Title: Sleep Medicine Clinics Volume: 5 Pages: 9-35
  • Peer Reviewed
• [Journal Article] Heterogeneous activity level of jaw-closing and -opening muscles and its association with arousal levels during sleep in the guinea pig. (2010)
  • Author(s): Kato T., et al.
  • Journal Title: American journal of physiology. Regulatory, inte grative and comparative physiology 298 Pages: 34-42
  • Peer Reviewed
• [Journal Article] Temporal alteration of chewing jaw movements after a reversible biteraising in guinea pigs. (2010)
  • Author(s): Kanayama H., et al.
  • Journal Title: Archives of Oral Biology 55 Pages: 89-94
  • Peer Reviewed
• [Journal Article] 咀嚼:「味」から「おいしさ」へ (2009)
  • Author(s): 加藤隆史, 増田裕次, 森本俊文
  • Journal Title: 日本味と匂い誌 16(1) Pages: 43-51
  • Peer Reviewed
• [Journal Article] 顎口腔系の機能との関係.特集:児童生徒の"こころ"に向き合う学校歯科保健-歯・口腔にみられる所見・症状と学校歯科医の課題- (2009)
  • Author(s): 加藤隆史, 神山潤
  • Journal Title: 日本学校歯科医会会誌 103(1) Pages: 12-15
• [Journal Article] 顎口腔系の機能との関係. 特集 : 児童生徒の "こころ" に向き合う学校歯科保健-歯・口腔にみられる所見・症状と学校歯科医の課題- (2009)
  • Author(s): 加藤隆史, ら
  • Journal Title: 日本学校歯科医会会誌 103 Pages: 12-15
• [Journal Article] 咀嚼 :「味」から「おいしさ」へ (2009)
  • Author(s): 加藤隆史, ら
  • Journal Title: 日本味と匂い誌 16 Pages: 43-51
  • Peer Reviewed
• [Journal Article] OSASと睡眠時ブラキシズム (2009)
  • Author(s): 加藤隆史
  • Journal Title: 睡眠医療 3 Pages: 535-540
• [Presentation] 睡眠中の自律神経活動と一過性の覚醒 (2010)
  • Author(s): 加藤隆史
  • Organizer: 第25回生体・生理工学シンポジウム(BPES2010)'心不全における自律神経系および呼吸異常の病態メカニズム'
  • Year and Date: 2010-09-24
• [Presentation] 睡眠中の自律神経活動と一過性の覚醒 (2010)
  • Author(s): 加藤隆史
  • Organizer: 第25回生体・生理工学シンポジウム(BPES2010)
  • Place of Presentation: 岡山(招待講演)
  • Year and Date: 2010-09-24
• [Presentation] 睡眠中の顎口腔運動とその異常 (2010)
  • Author(s): 加藤隆史
  • Organizer: 第52回歯科基礎医学会'顎顔面口腔機能は大脳によってどのように制御されるか?'
  • Year and Date: 2010-09-20
• [Presentation] 睡眠中の顎口腔運動とその異常 (2010)
  • Author(s): 加藤隆史
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-09-20
• [Presentation] Rhythmic masseter twitches in REM sleep of the guinea pig (2010)
  • Author(s): Kato T, et al.
  • Organizer: International Association for Dental Research
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] Rhythmic Masseter Twitches In REM Sleep Of The Guinea Pig. (2010)
  • Author(s): T.KATO, N.NAKAMURA^2, Y.MASUDA^2, T.ADACHI^2, A.YOSHIDA^1, T.MORIMOTO
  • Organizer: The 88^<th> general session & exhibition of the IADR, #2781
  • Place of Presentation: Spain, Barcelona
  • Year and Date: 2010-07-13
• [Presentation] 睡眠関連運動異常症としての睡眠時ブラキシズム (2010)
  • Author(s): 加藤隆史
  • Organizer: 日本睡眠学会'睡眠時ブラキシズムと睡眠障害・歯科的問題との関連'
  • Year and Date: 2010-07-02
• [Presentation] 睡眠関連運動異常症としての睡眠時ブラキシズム (2010)
  • Author(s): 加藤隆史
  • Organizer: 日本睡眠学会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2010-07-02
• [Presentation] ラット大脳皮質一次体性感覚野ニューロンの三叉神経運動前ニューロンへの投射様態 (2009)
  • Author(s): 飯田千絵, ら
  • Organizer: 第43回日本解剖学会近畿支部学術大会
  • Place of Presentation: 奈良
  • Year and Date: 2009-11-28
• [Presentation] ラット三叉神経運動前ニューロン群に投射する大脳皮質部位と視床との神経連絡. (2009)
  • Author(s): 山本真也
  • Organizer: 第43回顎口腔機能学会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-28
• [Presentation] Overview of sleep bruxism. (2009)
  • Author(s): Kato T.
  • Organizer: Korean Society of Sleep Medicine 09
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2009-11-21
• [Presentation] Bruxism in PSG. (2009)
  • Author(s): Kato T.
  • Organizer: Korean Society of Sleep Medicine 09
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-11-20
• [Presentation] 睡眠関連疾患と歯科-歯ぎしりは疾患か?- (2009)
  • Author(s): 加藤隆史
  • Organizer: 第16回日本未病システム学会学術総会
  • Year and Date: 2009-11-01
• [Presentation] 睡眠医学と歯科医学のmissing link-睡眠時ブラキシズムの研究から- (2009)
  • Author(s): 加藤隆史
  • Organizer: 第8回日本睡眠歯科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-27
• [Presentation] 睡眠医学と歯科医学の missing link-睡眠時ブラキシズムの研究から- (2009)
  • Author(s): 加藤隆史
  • Organizer: 第8回日本睡眠歯科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-27
• [Presentation] Sleep bruxism: an overview from sleep medicine. (2009)
  • Author(s): Kato T.
  • Organizer: The International Academy of Advanced Interdisciplinary Dentistry, 'Sleep Medicine and Sleep Bruxism'
  • Place of Presentation: Tokyo
  • Year and Date: 2009-09-23
• [Presentation] Sleep bruxism : an overview from sleep medicine. (2009)
  • Author(s): Kato T.
  • Organizer: The International Academy of Advanced Interdis ciplinary Dentistry
  • Place of Presentation: Tokyo.
  • Year and Date: 2009-09-23
• [Presentation] Overview of sleep bruxism. (2009)
  • Author(s): Kato T.
  • Organizer: Korean Society of Sleep Medicine 09
  • Place of Presentation: Seoul Korea
  • Year and Date: 2009-09-21
• [Presentation] 安静時におけるモルモット閉口筋筋感覚ニューロン活動の変化 (2009)
  • Author(s): 中村典正, 加藤隆史, 足立忠文, 山下秀一郎, 森本俊文, 増田裕次
  • Organizer: 第51回歯科基礎医学会
  • Year and Date: 2009-09-11
• [Presentation] 安静時におけるモルモット閉口筋筋感覚ニューロン活動の変化 (2009)
  • Author(s): 中村典正, ら
  • Organizer: 第51回歯科基礎医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-11
• [Presentation] モルモットを用いた実験的咬合高径低下 (2009)
  • Author(s): 金山隼人, 加藤隆史, 足立忠文, 山田一尋, 森本俊文, 増田裕次
  • Organizer: 第51回歯科基礎医学会
  • Year and Date: 2009-09-10
• [Presentation] 脳と睡眠からブラキシズムを考える (2009)
  • Author(s): 加藤隆史
  • Organizer: 第118回日本補綴歯科学会学術大会
  • Year and Date: 2009-06-05
• [Presentation] Masticatory muscle activity and arousal levels in sleeping guinea pigs. (2009)
  • Author(s): Kato T., et al.
  • Organizer: The 87^<th> general session & exhibition of the IADR
  • Place of Presentation: Miami, USA
  • Year and Date: 2009-04-02
• [Book] physiological interpretation for clinical dentistry.(edited by Paesani D)(The role of peripheral sensory factors in bruxism)(In : Bruxism : Theory and Practice) (2010)
  • Author(s): Kato T.
  • Publisher: Quintessense
• [Book] 歯ぎしり.小児科臨床ピクシス14-こどもの眠り-(総編集:五十嵐正,専門編集:神山潤) (2010)
  • Author(s): 加藤隆史, 加藤久美
  • Publisher: 中山書店
• [Book] 歯科医師のための睡眠医学:その実践と概要(古谷野潔監訳)(睡眠時の口腔顔面異常症) (2010)
  • Author(s): 加藤隆史, 三上章良
  • Publisher: クインテッセンス
• [Book] 歯科医師のための睡眠医学:その実践と概要(古谷野潔監訳)(睡眠の神経生物学) (2010)
  • Author(s): 加藤隆史
  • Publisher: クインテッセンス
• [Book] 歯科医師のための睡眠医学:その実践と概要(古谷野潔監訳) (2010)
  • Author(s): 加藤隆史、三上章良
  • Publisher: クインテッセンス
• [Book] 歯科医師のための睡眠医学:その実践と概要(古谷野潔監訳) (2010)
  • Author(s): 加藤隆史
  • Publisher: クインテッセンス
• [Book] 小児科臨床ピクシス14-こどもの眠り- (2010)
  • Author(s): 加藤隆史, ら
  • Publisher: 中山書店
• [Book] In : Sleep Medicine for Dentists(edited by Lavigne GJ et al.)(Orofacial related movement disorders in sleep) (2009)
  • Author(s): Kato T, Blanchet P.
  • Publisher: Quintessence
• [Book] Sleep Medicine for Dentists (2009)
  • Author(s): Kato T., et al.
  • Publisher: Quintessence