| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Hyperpolarization-activated cation channel (Ih channel) acts as the pacemaker in the central nervous system, and the functional role of Ih channel in the area postrema (AP) has not been fully understood. So the aim of this study was to elucidate the electrophysiological role of Ih channel, the activation for cevimeline in AP and the mechanism of nausea and vomiting. This study suggests that AP neurons may contribute to the cevimeline-induced nausea and vomiting.
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