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The role of DCs in Ni allergy development in the mouse model

Research Project

Project/Area Number 21791901
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Prosthetic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

WATANABE Megumi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40380050)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords金属アレルギー / 樹状細胞 / MAPキナーゼ / ニッケル
Research Abstract

We have analyzed Ni allergy symptoms in focus on dendritic cells in the mouse model we produced. In this study, we regulated MKK6 expression and activation to regulate Ni allergy symptoms in our mouse model. In addition, we found activation of RhoA after the stimulation with Ni. From these data, it may be possible to control Ni allergy by regulation of small G-protein in dendritic cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results)

  • [Journal Article] A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice2011

    • Author(s)
      Megumi Watanabe, Naozumi Ishimaru, Meinar Nur Ashrin, Rieko Arakaki, Akiko Yamada, Tetsuo Ichikawa, and Yoshio Hayashi
    • Journal Title

      PLoS ONE

      Volume: 6(4) Issue: 4 Pages: e19017-e19017

    • DOI

      10.1371/journal.pone.0019017

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice2011

    • Author(s)
      Megumi Watanabe, et al.
    • Journal Title

      PLoS ONE

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] he Role of MKK6/ p38 Signal Cascade in Dendritic Cells in Mickel Allergy Mouse Model2011

    • Author(s)
      Megumi Watanabe
    • Organizer
      Kalimantan Symposia
    • Place of Presentation
      バリクパパン(インドネシア)
    • Year and Date
      2011-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] The Role of MKK6/p38 Signal Cascade in Dendritic Cells in Nickel Allergy Mouse Model2011

    • Author(s)
      Watanabe, M
    • Organizer
      Kalimantan Symposia
    • Place of Presentation
      バリクパパン(インドネシア)
    • Year and Date
      2011-12-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] インプラント材料とアレルギー2011

    • Author(s)
      渡邉恵
    • Organizer
      第41回公益社団法人日本口腔インプラント学会・学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] インプラント材料とアレルギー2011

    • Author(s)
      渡邉恵
    • Organizer
      第41回公益社団法人日本口腔インプラント学会・学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)(招待講演)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Extremely Low Frequency Pulsed Magnetic Fields Accelerate Osteoblast Differentiation2011

    • Author(s)
      Megumi Watanabe
    • Organizer
      ICP 14th Biennial Meeting
    • Place of Presentation
      ハワイ(米国)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Analysis of Molecular Mechanism for Pathogenesis of Metal Allergy2010

    • Author(s)
      Meinar Nur Ashrin, et al.
    • Organizer
      International Joint Symposium on Oral Science
    • Place of Presentation
      Kuta, Bali
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Extremely Low Frequency Pulsed Magnetic Fields Accelerate Osteoblast Differentiation2010

    • Author(s)
      Megumi Watanabe
    • Organizer
      European Academy of Osseointegration
    • Place of Presentation
      グラスゴー(英国
    • Year and Date
      2010-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Extremely Low Frequency Pulsed Magnetic Fields Accelerate Osteoblast Differentiation2010

    • Author(s)
      Megumi Watanabe, et al.
    • Organizer
      European Academy of Osseointegration
    • Place of Presentation
      Glasgow
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニッケルアレルギーモデルマウス樹状細胞におけるシグナル伝達の解析2010

    • Author(s)
      渡邉恵
    • Organizer
      第2回「口腔環境制御研究」カテゴリー集会
    • Place of Presentation
      長崎大学(長崎市)
    • Year and Date
      2010-02-10
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ニッケルアレルギーモデルマウス樹状細胞におけるシグナル伝達の解析2009

    • Author(s)
      渡邉恵
    • Organizer
      口腔からQOL向上を目指す連携研究ミニシンポジウム
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2009-10-16
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] MKK6/ p38 Signal Transduction Cascades Regulate Nickel Allergy in the Model Mouse2009

    • Author(s)
      Watanabe, M
    • Organizer
      International College of Prosthodontics
    • Place of Presentation
      ケープタウン(南アフリカ)
    • Year and Date
      2009-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] MKK6/p38 Signal Transduction Cascades Regulate Nickel Allergy in the Model Mouse2009

    • Author(s)
      Watanabe, M.
    • Organizer
      International College of Prosthodontics
    • Place of Presentation
      Cape Town
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニッケルアレルギーモデルマウス樹状細胞におけるシグナル伝達の解析2009

    • Author(s)
      渡邉恵
    • Organizer
      (社)日本補綴歯科学会第118回学術大会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2009-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] ニッケルアレルギーモデルマウス樹状細胞におけるシグナル伝達の解析2009

    • Author(s)
      渡邉恵
    • Organizer
      (社)日本補綴歯科学会第118回学術大会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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