Development of the novel noninvasive bone augmentation technique

• Project/Area Number: 21791907
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu University
• Principal Investigator: JINNO Yohei Kyushu University, 歯学研究院, 助教 (40507779)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 骨増生 / 歯科用インプラント / スタチン / 非侵襲 / 骨

Research Abstract

Within the limitation of our study, we suggest that a single-shot percutaneous injection of fluvastatin with a collagen-α-tricalcium phpsphate (αTCP) composite induces new bone formation in a vertical direction around and under the composite(calvarial bone of rat). However, it is very difficult to obtain new bone on the alveolar bone (rat, dog). Further study is needed for clinical application. (ideal concentration of fluvastatin, investigation of the novel drug delivery system)

Research Products

• [Journal Article] Vertical bone augmentation with fluvastatin in an injectable delivery system : a rat study. (2009)
  • Author(s): Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyaka Y, Koyano K
  • Journal Title: Clin Oral Implants Res 8 Pages: 756-760
  • Peer Reviewed
• [Journal Article] The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid)microspheres on osteogenesis around titanium implants in rat tibiae. (2009)
  • Author(s): Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino Y, Koyano K
  • Journal Title: Biomaterials 12 Pages: 3327-3334
  • Peer Reviewed
• [Journal Article] Simvastatin enhances bone formation around titanium implants in rat tibiae. (2009)
  • Author(s): Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K
  • Journal Title: J Oral Rehabil 2 Pages: 123-130
  • Peer Reviewed
• [Journal Article] Vertical bone augmentation with fluvastatin in an injectable delivery system : a rat study. (2009)
  • Author(s): Jinno Y, et al
  • Journal Title: Clin Oral Implants Res 8 Pages: 756-760
  • Peer Reviewed
• [Journal Article] The eddect of a single remote injection of statin-impregnated poly (lactiv-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia. (2009)
  • Author(s): Masuzaki T, et al
  • Journal Title: Biomaterials 12 Pages: 3327-3334
  • Peer Reviewed
• [Journal Article] Simvastatin enhances bone formation around titanium implants in rat tibiae. (2009)
  • Author(s): Ayukawa Y, et al.
  • Journal Title: J Oral Rehabil 2 Pages: 123-130
  • Peer Reviewed
• [Presentation] A New Statin Delivery System to Improve the Bone Thickness (2009)
  • Author(s): Jinno Y, et al
  • Organizer: 5th Scientific Meeting Asian Academy of Osseointegration
  • Place of Presentation: インドネシア バリ
• [Presentation] A New Statin Delivery System to Improve the Bone Thickness (2009)
  • Author(s): Jinno Y, et al
  • Organizer: 5^<th> Scientific Meeting Asian Academy of Osseointegration
  • Place of Presentation: インドネジア バリ