Evaluation of bone metabolic activity around dental implants in OVX rat model using Fine PET

• Project/Area Number: 21791931
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tohoku University
• Principal Investigator: SASAKI Hiroto Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (60431582)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: インプラント / 骨粗鬆症 / 骨代謝 / PET / 力的負荷

Research Abstract

The bone metabolic activity around dental implants initially increased until 7 days. Afterwards, they gradually decreased from the peak level to the pre-loading level despite a static force being applied to the implants. Additionally, the activity at the superior part of traction side showed significantly high value compared with those of other parts at 7 days. Early loading to the implant initially enhanced the bone metabolism around the implant, especially at the part with compressive stress ; however, metabolic activity returned to pre-loading level with time.

Research Products

• [Presentation] Influence of early loading on bone metabolism around dental implants in rat tibia (2011)
  • Author(s): M.Yamamoto, M.Yokoyama, S.Koyama, H.Sasaki, Y.Funaki, Y.Kikuchi, H.Yamazaki, K.Ishii, K.Sasaki
  • Organizer: Harvard-Forsyth-Tohoku Research Workshop
  • Place of Presentation: Harvard University, Cambridge, MA, USA
• [Presentation] Influence of early loading on bone metabolic activity around dental implants (2010)
  • Author(s): M.Yamamoto, M.Yokoyama, S.Koyama, H.Sasaki, Y.Funaki, Y.Kikuchi, H.Yamazaki, K.Ishii, K.Sasaki
  • Organizer: IADR (International Association for Dental Research) GENERAL SESSION 2010
  • Place of Presentation: Center Convencions International Barcelona, BARCELONA,SPAIN
• [Presentation] Influence of early loading on bone metabolic activity around dental implants (2010)
  • Author(s): M.Yamamoto, M.Yokoyama, S.Koyama, H.Sasaki, Y.Funaki, Y.Kikuchi, H.Yamazaki, K.Ishii, K.Sasaki
  • Organizer: IADR (International Association for Dental Research) GENERAL SESSION 2010
  • Place of Presentation: Center Convencions International Barcelona, BARCELONA, SPAIN
• [Presentation] 高解像度PETを用いた即時,早期荷重負荷時の歯科インプラント周囲骨代謝活性に関する研究 (2009)
  • Author(s): 山本未央, 横山政宣, 佐々木洋人, 小山重人, 船木善仁, 菊池洋平, 中村賢司, 中沢浩一, 山崎浩道, 石井慶造, 佐々木啓一
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台仙台国際センター
  • Year and Date: 2009-06-16
• [Presentation] 高解像度PETを用いた即時, 早期荷重負荷時の歯科インプラント周囲骨代謝活性に関する研究 (2009)
  • Author(s): 山本未央, 横山政宣, 佐々木洋人, 小山重人, 船木善仁, 菊池洋平, 中村賢司, 中沢浩, 山崎浩道, 石井慶造, 佐々木啓一
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2009-06-16
• [Presentation] 即時荷重,早期荷重負荷の相違がインプラント周囲骨代謝活性に及ぼす影響 (2009)
  • Author(s): 山本未央, 横山政宣, 小山重人, 佐々木洋人, 佐々木啓一
  • Organizer: 第39回日本口腔インプラント学会学術大会
  • Place of Presentation: 大阪大阪国際会議場
• [Presentation] 即時荷重, 早期荷重負荷の相違がインプラント周囲骨代謝活性に及ぼす影響 (2009)
  • Author(s): 山本未央, 横山政宣, 小山重人, 佐々木洋人, 佐々木啓一
  • Organizer: 第39回日本口腔インプラント学会学術大会
  • Place of Presentation: 大阪 大阪国際会議場
• [Remarks] ホームページ等