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Development of a novel disinfection technique based on photodynamic therapy

Research Project

Project/Area Number 21791932
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

NAKAMURA Keisuke  東北大学, 未来科学技術共同研究センター, 助教 (30431589)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords光線力学療法 / 一重項酸素 / 活性酸素 / 殺菌 / 光線力学殺菌療法
Research Abstract

In the present study, it was demonstrated that singlet oxygen generated in photodynamic therapy could effectively kill Streptococcus aureus. In addition, a quantitative analytical method for singlet oxygen generated in photodynamic therapy has been established. It was demonstrated that electron spin resonance technique using sterically hindered amine was suitable for the measurement. The analysis showed that the yield of singlet oxygen increased with the irradiation time and the concentration of photosensitizer.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 10 results) Presentation (16 results) Book (4 results)

  • [Journal Article] Reevaluation of An alytical Methods for Photogenerated Singlet Oxygen2011

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      J Clin Biochem Nutr

      Volume: (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of Analytical Methods for Photogenerated Singlet Oxygen2011

    • Author(s)
      Nakamura K, et al
    • Journal Title

      J Clin Biochem Nutr

      Volume: (未定)(accepted)

    • NAID

      130004466651

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photolysis of hydrogen peroxide, an effective disinfection system via hydroxyl radical formation2010

    • Author(s)
      Ikai H, Nakamura K, et al.
    • Journal Title

      Antimicrob Agents Chemo ther

      Volume: 54 Pages: 5086-5091

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel analytical method to evaluate directly catalase activity of microorganisms and mammalian cells by ESR oximetry2010

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      Free Radical Res

      Volume: 44 Pages: 1036-1043

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of quantitative ESR spin trapping analysis of hydroxyl radical by applying sonolysis of water as a model system2010

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      Bull Chem Soc Jpn

      Volume: 83 Pages: 1037-1046

    • NAID

      10026698287

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zirconia as a dental implant abutment material: A systematic review2010

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      Int J Prosthodont

      Volume: 23 Pages: 299-309

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bactericidal effect of photodynamic therapy2010

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      (Springer)

      Pages: 232-233

    • Related Report
      2010 Final Research Report
  • [Journal Article] Denture plaque removal efficacy of denture cleansing device utilizing radical disinfection ability of activated low concentration H2O22010

    • Author(s)
      Kanno T, Hayashi E, Ikai H, Nakamura K, et al.
    • Journal Title

      (Springer)

      Pages: 252-253

    • Related Report
      2010 Final Research Report
  • [Journal Article] Transmitted laser beam power of the resin washed by experimental washing machine for dentures2010

    • Author(s)
      Hayashi E, Tada M, Kanno T, Ikai H, Nakamura K, et al.
    • Journal Title

      (Springer)

      Pages: 255-256

    • Related Report
      2010 Final Research Report
  • [Journal Article] The evaluation of the dental disinfection device with low concentration of H2O2 and laser diode2010

    • Author(s)
      Ikai H, Kanno T, Nakamura K, et al.
    • Journal Title

      (Springer)

      Pages: 257-258

    • Related Report
      2010 Final Research Report
  • [Journal Article] Photolysis of hydrogen peroxide, an effective disinfection system via h roxyl radical formation2010

    • Author(s)
      Ikai H, Nakamura K, et al
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54 Pages: 5086-5091

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel analytical method to evaluate directly catalase activity of mic organisms and mammalian cells by ESR oximetry2010

    • Author(s)
      Nakamura K, et al
    • Journal Title

      Free Radical Res

      Volume: 44 Pages: 1036-1043

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of quantitative ESR spin trapping analysis of hydroxyl dical by applying sonolysis of water as a model system2010

    • Author(s)
      Nakamura K, et al
    • Journal Title

      Bull Chem Soc Jpn

      Volume: 83 Pages: 1037-1046

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zirconia as a dental implant abutment material : A systematic review2010

    • Author(s)
      Nakamura K, et al
    • Journal Title

      Int J Prosthodontics

      Volume: 23 Pages: 299-309

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bactericidal effect of photodynamic therapy2010

    • Author(s)
      Keisuke Nakamura, et al.
    • Journal Title

      Interface Oral Health Science 2009 (in press)

      Pages: 232-233

    • Related Report
      2009 Annual Research Report
  • [Presentation] Reevaluation of Analytical Methods for Photogenerated Singlet Oxygen2011

    • Author(s)
      Ishiyama K, Nakamura K, et al.
    • Organizer
      The 4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Influence of hydroxyl radical generated by photolysis of H_2O_2 on corrosion behavior of dental metals2011

    • Author(s)
      Yamada Y, Nakamura K, et al.
    • Organizer
      The 4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Bactericidal effect of hydroxyl radical generated by photolysis of hydrogen peroxide2011

    • Author(s)
      Ikai H, Nakamura K, et al.
    • Organizer
      The 4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Booster effect of thermal energy on bactericidal action of hydroxyl radical generated by photolysis of H_2O22011

    • Author(s)
      Shirato M, Ikai H, Nakamura K, et al.
    • Organizer
      The 4th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Reevaluation of Analytical Methods for Photogenerated Singlet Oxyge2011

    • Author(s)
      Ishiyama K, Nakamura K, et al
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      ホテル仙台プラザ
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Influence of hydroxyl radical generated by photolysis of H_2O_2 on cor on behavior of dental metals2011

    • Author(s)
      Yamada Y, Nakamura K, et al
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      ホテル仙台プラザ
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bactericidal effect of hydroxyl radical generated by photolysis of hyd en peroxide2011

    • Author(s)
      Ikai H, Nakamura K, et al
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      ホテル仙台プラザ
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Booster effect of thermal energy on bactericidal action of hydroxyl radical generated by photolysis of H_2O_22011

    • Author(s)
      Shirato M, Ikai H, Nakamura K, et al
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      ホテル仙台プラザ
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光線力学殺菌療法における一重項酸素生成量評価法の検討2010

    • Author(s)
      石山希里香, 中村圭祐, ら
    • Organizer
      第25回日本酸化ストレス学会関東支部学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 過酸化水素光分解殺菌法における殺菌効果増強因子の検討2010

    • Author(s)
      白土翠, 猪飼紘代, 中村圭祐, ら
    • Organizer
      第25回日本酸化ストレス学会関東支部学術大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光線力学殺菌療法における-重項酸素生成量評価法の検討2010

    • Author(s)
      石山希里香, 史村圭祐, ら
    • Organizer
      第25回日本酸化ストレス学会関東支部学術大会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] ESRオキシメトリー法を応用した微生物および動物細胞の新しいカタラーゼ活性測定法2010

    • Author(s)
      中村圭祐, ら
    • Organizer
      第63回日本酸化ストレス学会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 過酸化水素の光分解によるHO・生成反応の活性化2010

    • Author(s)
      白土翠, 中村圭祐, ら
    • Organizer
      第63回日本酸化ストレス学会
    • Place of Presentation
      神奈川県県民ホール
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 過酸化水素光分解から生じたヒドロキシルラジカル殺菌効果2010

    • Author(s)
      猪飼紘代, 中村圭祐, ら
    • Organizer
      第63回日本酸化ストレス学会
    • Place of Presentation
      神奈川県県民ホール
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ESRスピントラップ法を用いたラジカル定量の潜在的問題点2010

    • Author(s)
      佐藤恵美子, 中村圭祐, ら
    • Organizer
      第63回日本酸化ストレス学会
    • Place of Presentation
      神奈川県県民ホール
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ESEオキシメトリー法を応用した微生物および動物細胞の新しいカタラーゼ活性測定法2010

    • Author(s)
      中村圭祐, ら
    • Organizer
      第63回日本酸化ストレス学会
    • Place of Presentation
      神奈川県県民ホール
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Book] Interface Oral Health Science 2009 (Editors T.Sasano, O.Suzuki)2010

    • Author(s)
      Nakamura K, et al
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] Interface Oral Health Science 2009 (Editors T.Sasano, O.Suzuki)2010

    • Author(s)
      Kanno T, Hayashi E, Ikai H, Nakamura K, et al
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] Interface Oral Health Science 2009 (Editors T.Sasano, O.Suzuki)2010

    • Author(s)
      Hayashi E, Tada M, Kanno T, Ikai H, Nakainura K, et al
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] Interface Oral Health Science 2009 (Editors T.Sasano, O.Suzuki)2010

    • Author(s)
      Ikai H, Kanno T, Nakamura K, et al
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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