| Project/Area Number |
21791939
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagasaki University (2010)
Hiroshima University (2009) |
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Principal Investigator |
SUEHIRO Fumio Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (40524781)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 再生医療 / 幹細胞 / 骨再生 / 遺伝子 / 細胞移植 / 間葉系幹細胞 / 骨分化 / 転写因子 |
|---|
| Research Abstract |
I had identified eleven novel transcription factors that involves in human Mesenchymal stem cells (MSC) osteogenesis. Interaction of these factors might progress MSC osteogenic differentiation. Especially, factors which suppress osteogenic differentiation might show negative feedback toward osteogenic differentiation. Clinical application of these transcription factors, especially two factors, might be used for prognostic marker for osteogenic potential of MSC and may be useful for quality check before MSC transplantation in the future medicine.
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