| Project/Area Number |
21791946
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
NAGANO Futami Health Sciences University of Hokkaido, 歯学部, 助教 (10534448)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生体材料学 / ナノ材料 / タンパク質 / 抗菌性 / 口腔組織 |
|---|
| Research Abstract |
The aim of this study was to evaluate the induction of antimicrobial protein, such as S100A7, S100A15 and Chromogranin A by stimulation of colloid solution of platinum nanoparticles (CPN) on human gingival fibroblast, pulp fibroblast and KB cell. We proved that CPN induced the expression of antimicrobial protein. Also we found that the induction of gene expression of all the candidate genes was necessarily bound to the induction of the MAP-Kinase pathway like ERK 1/2, p-38 and JNK as proved by Immunoblotting experiments. ASK involvement as well as the phosphorylation of ASK has been evidenced in our experiments.
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