The development of implant material by controlling adhesive protein

• Project/Area Number: 21791951
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: KOKUBU Eitoyo Tokyo Dental College, 微生物学講座, 助教 (70453785)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 歯科インプラント学 / 歯科インプラント / 接着タンパク / 免疫機能 / 骨髄細胞

Research Abstract

The titanium substance treated with polish or sandblast-etched were made. The epithelial rests of malassez were cultured on the substance to evaluate the aging with time. The cells were decrease a proliferation and a expression of total-ERK and focal adhesive kinase protein.

Research Products

• [Journal Article] Immediate loading after implant placement following tooth extraction up-regulates cellular activity in the dog mandible. (2011)
  • Author(s): 佐藤隆太、松坂賢一、国分栄仁、井上孝
  • Journal Title: Clinical Oral Implants Research Volume: DOI:10.1111/j.1600-0501.2010.02118.x
  • Peer Reviewed
• [Journal Article] Effects of epidermal growth factor and/or nerve growth factor on Malassez' s epithelial rest cells in vitro : expression of mRNA for osteopontin, bone morphogenetic protein 2 and vascular endothelial growth factor (2010)
  • Author(s): 山脇健史、松坂賢一、国分栄仁、井上孝
  • Journal Title: Journal of Periodontal Research 45(3) Pages: 421-427
  • Peer Reviewed
• [Journal Article] Analysis of side population cells derived from dental pulp tissue (2010)
  • Author(s): 監物真、松坂賢一、国分栄仁、東俊文、井上孝
  • Journal Title: International Endodontic Journal 43(12) Pages: 1132-42
  • Peer Reviewed
• [Journal Article] Effect of mechanical loading on cultured osteogenic cells derived from different stages of bone wound healing in rats : experimental models for immediate or early implantation (2010)
  • Author(s): 佐藤大輔、松坂賢一、国分栄仁、井上孝
  • Journal Title: Oral Medicine & Pathology 14 Pages: 143-151
  • NAID: 130004509538
  • Peer Reviewed
• [Journal Article] Age-related differences in the expression of heat shock protein 27 by rat periodontal ligament cells in culture (2010)
  • Author(s): 松坂賢一、国分栄仁, 他6名
  • Journal Title: Oral Medicine & Pathology 14 Pages: 131-134
  • NAID: 130004509536
  • Peer Reviewed
• [Journal Article] Analysis of side population cells derived from dental pulp tissue. (2010)
  • Author(s): 監物真、松坂賢一、国分栄仁、東俊文、井上孝
  • Journal Title: International Endodontic Journal Volume: 43 Pages: 221-231
  • Peer Reviewed
• [Journal Article] Effects of epidermal growth factor and/or nerve growth factor on Malassez's epithelial rest cells in vitro : expression of mRNA for osteopontin, bone morphogenetic protein 2 and vascular endothelial growth factor. (2010)
  • Author(s): 山脇健史、松坂賢一、国分栄仁、井上孝
  • Journal Title: Journal Periodontal Research Volume: 45 Pages: 421-427
  • Peer Reviewed
• [Journal Article] Behavior of rat periodontal ligament cells on fibroblast growth factor-2 immobilized titanium urfaces treated by plasma modification (2009)
  • Author(s): 国分栄仁、Hamilton DW、井上孝
  • Journal Title: Journal of biomedical materials research. Part A 91 Pages: 69-75
  • Peer Reviewed
• [Journal Article] Behavior of rat periodontal ligament cells on fibroblast growth factor-2-immobilized titanium surfaces treated by plasma modification. (2009)
  • Author(s): 国分栄仁
  • Journal Title: Journal of biomedical materials research. Part A 91 Pages: 69-75
  • Peer Reviewed
• [Presentation] Treponema denticolaの細胞侵入に対するMalassez上皮遺残細胞の細胞動態 (2010)
  • Author(s): 国分栄仁、稲垣覚、君塚隆太、石原和幸
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: 東京
• [Presentation] Treponema denticolaの細胞侵入に対するMalassez上皮遺残細胞の細胞動態 (2010)
  • Author(s): 国分栄仁、稲垣覚、君塚隆太、石原和幸
  • Organizer: 歯科基礎医学会
  • Place of Presentation: タワーホール船堀(東京)