| Project/Area Number |
21791959
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College (2010)
Japanese Foundation For Cancer Research (2009) |
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Principal Investigator |
KOKUBUN Katsutoshi Tokyo Dental College, 歯学部, 助教 (90535808)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯学 / インプラント / チタン / ナノ材料 / 人工タンパク質 / 表面改質 / DDS / 生体材料 / 人工ペプチド |
|---|
| Research Abstract |
Modification of the surfaces of materials, such as titanium, is important in the medical engineering area. We are employing our "carbon nanomaterials" and "motif-programmed artificial proteins" methodology in order to biologically modify the surface of titanium. We have demonstrated that DEX (Dexamethasone)-CNH on titanium attractive candidates four use in a novel drug delivery system. DEX-CNH exhibited sustained release of biologically active DEX in mammalian cells without significant side effects. Furthermore, we successfully created artificial proteins that contain embedding cell attachment and Ti-binding motifs and endowed Ti with cell attachment activity.
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