The judgment of oral carcinoma which shows tolerance to the chemotherapy by miRNA in serum.
Project/Area Number |
21791960
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
MATSUDA Aya 北海道大学, 大学院・歯学研究科, 学術研究員 (60514312)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,649,855 (Direct Cost: ¥3,576,812、Indirect Cost: ¥1,073,043)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥359,855 (Direct Cost: ¥276,812、Indirect Cost: ¥83,043)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 臨床腫瘍学 / 化学療法耐性癌 / 口腔癌 / miRNA / シスプラチン / 化学療法 |
Research Abstract |
The cisplatin resistant cell and the cisplatin sensitive cell were established from the oral carcinoma cell line. The genes which participate in cisplatin tolerance using these cells, and miRNAs combined with the genes were searched. It was suggested that the expression patterns of miRNA change cisplatin resistant, and miRNA in blood is participating in malignancy of oral carcinoma.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment2012
Author(s)
Akiyama K, Ohga N, Hida Y, Kawamoto T, SadamotoY, Ishikawa S, Akino T, Kondoh M, Maishi N, Matsuda A, Inoue N, Shindoh M, Hida K.
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Journal Title
Am J Pathol
Volume: 180
Pages: 1283-93
Related Report
Peer Reviewed
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