The judgment of oral carcinoma which shows tolerance to the chemotherapy by miRNA in serum.

• Project/Area Number: 21791960
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: MATSUDA Aya 北海道大学, 大学院・歯学研究科, 学術研究員 (60514312)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,649,855 (Direct Cost: ¥3,576,812、Indirect Cost: ¥1,073,043); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥359,855 (Direct Cost: ¥276,812、Indirect Cost: ¥83,043); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床腫瘍学 / 化学療法耐性癌 / 口腔癌 / miRNA / シスプラチン / 化学療法

Research Abstract

The cisplatin resistant cell and the cisplatin sensitive cell were established from the oral carcinoma cell line. The genes which participate in cisplatin tolerance using these cells, and miRNAs combined with the genes were searched. It was suggested that the expression patterns of miRNA change cisplatin resistant, and miRNA in blood is participating in malignancy of oral carcinoma.

Research Products

• [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment (2012)
  • Author(s): Akiyama K, Ohga N, Hida Y, Kawamoto T, SadamotoY, Ishikawa S, Akino T, Kondoh M, Maishi N, Matsuda A, Inoue N, Shindoh M, Hida K.
  • Journal Title: Am J Pathol Volume: 180 Pages: 1283-93
  • Peer Reviewed
• [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment (2012)
  • Author(s): Akiyama K, Matsuda A, 10番目, et al
  • Journal Title: The American journal of pathology Volume: 180 Pages: 1283-93
  • Peer Reviewed
• [Journal Article] 新しい口腔癌の発生メカニズムとのトランスレーショナルリサーチ (2011)
  • Author(s): 東野史裕、北村哲也、柳川-松田彩、進藤正信
  • Journal Title: 北海道歯学会誌 Volume: 32巻 Pages: 65-67
  • Peer Reviewed
• [Journal Article] 新しい口腔癌の発生メカニズムとのトランスレーショナルリサーチ (2011)
  • Author(s): 東野史裕、柳川-松田彩, 3番目
  • Journal Title: 北海道歯学会誌 Volume: 32 Pages: 65-67
• [Presentation] miR-214はアデノウイルスの増殖に抑制的にはたらく (2011)
  • Author(s): 松田彩、北村哲也、樋田京子、東野史裕、進藤正信
  • Organizer: 第22回日本臨床口腔病理学会、第5回アジア口腔病理学会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2011-08-24
• [Presentation] miR-214 can regulate adenovirus replication (2011)
  • Author(s): Yanagawa-Matsuda A, Kitamura T, Hida K, Higashino F, Shindoh M
  • Organizer: 第63回日本細胞生物学会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2011-06-27
• [Presentation] miR-214はE1Aをターゲットにしてアデノウイルス感染の抑制にはたらく (2011)
  • Author(s): 柳川彩、北村哲也、東野史裕、樋田京子、進藤正信
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-04-28
• [Presentation] miR-214はアデノウイルス初期遺伝子ElAの発現を抑制する (2009)
  • Author(s): 柳川彩
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-05-02