The development innovative treatment of oral cancer by photodynamic therapy, and basic research.

• Project/Area Number: 21791965
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hirosaki University
• Principal Investigator: NAKAGAWA Hiroshi Hirosaki University, 医学部附属病院, 医員 (00529688)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 口腔扁平上皮癌 / PDT / NPe6(レザフィリン) / 口腔扁平法事癌 / Npe6(レザフィリン)

Research Abstract

Leukoplakia and lichen planus in oral cavity are premalignant lesions, which are high rate recurrence in a long term, and the way of treatment has not established. The high rate of recurrence was suggested that the expression of angiogenesis factor. We investigated antitumor effect by NPe6 mediated PDT, inhibited the expression of angiogenesis factor.
As a result, we identified the gene and protein that contributes neoangiogenesis, and inhibited cell proliferation, migration, lumen formation.

Research Products

• [Remarks] ホームページ等