| Project/Area Number |
21791968
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MIZUTA Fumiko Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (30396501)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 気管支喘息 / GABAB受容体 / IP_3 / カルシウムイオン / GABA(B)受容体 / 気管支痙攣 / GABA(A)受容体 / Ca^<2+> |
|---|
| Research Abstract |
Although the functional expression of the GABA_B receptors coupled to the G_i protein has been reported on airway smooth muscle, the role of GABA_B receptors on airway responsiveness has been remained unclear. We investigated whether G_i-coupled GABA_B receptors cross-regulate phospholipase C (PLC), an enzyme classically regulated by G_q-coupled receptors (e.g. bradykinin receptor) in human airway smooth muscle (HASM) cells. Stimulation of GABA_B receptors on human airway smooth muscle cells rapidly mobilizes intracellular Ca^<2+> stores by IP_3 synthesis through the activation of PLC-β that was stimulated by G_<βγ> protein liberated from G_i proteins coupled to GABA_B receptors.
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