The elucidation of bone formation by PTH centering on G protein and its application to bone regeneration

• Project/Area Number: 21791973
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: SAIJYO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 副甲状腺ホルモン / 骨形成 / G蛋白 / PTHシグナル / Gαs / Gαq / 骨代謝調節機構 / 骨形成促進剤の開発

Research Abstract

The purpose of this study is to clarify regulatory mechanism of bone and cartilage metabolism by Gαs and Gαq signaling via PTH using TypeI collagen Cre ; Gαs-or Gαq-flox mice and TypeII collagen Cre ; Gαs-or Gαq-flox mice. In vitro, using constitutively active Gαs-or Gαq adenoviruses, we tried to clarify osteogenic and chondrogenic function via Gαs-or Gαq signaling.

Research Products

• [Journal Article] A novel method fordesigning and fabricating custom-made artificial bones (2011)
  • Author(s): Hideto. Saijo, et al
  • Journal Title: Int J Oral Maxillofac Surg Volume: 40 Pages: 955-960
  • Peer Reviewed
• [Journal Article] A novel method for designing and fabricating custom-made artificial bones (2011)
  • Author(s): Saijo H, 他
  • Journal Title: Int J Oral Maxillofac Surg Volume: 40 Issue: 9 Pages: 955-960
  • DOI: 10.1016/j.ijom.2011.03.018
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 activity is important in craniofacial fracture repair (2011)
  • Author(s): Chikazu D, Fujikawa Y, Fujihara H, Suenaga H, Saijo H, Ohkubo K, Ogasawara T, Mori Y, Iino M, Takato T
  • Journal Title: Int J Oral Maxillofac Surg. Volume: 40 Issue: 3 Pages: 322-326
  • DOI: 10.1016/j.ijom.2010.10.011
  • Peer Reviewed
• [Journal Article] Role of cyclin-dependent kinase (Cdk)6 in osteoblast, osteoclast, and chondrocyte differentiation and its potential as a target of bone regenerative medicine (2011)
  • Author(s): Toru Ogasawara, Yoshiyuki Mori, Masanobu Abe, Hideyuki Suenaga, Yoko Kawase-Koga, Hideto Saijo, Tsuyoshi Takato
  • Journal Title: Oral Science International Volume: 8 Issue: 1 Pages: 2-6
  • DOI: 10.1016/s1348-8643(11)00007-3
  • Peer Reviewed
• [Journal Article] Evaluation and analysis of bone formation at palate of cleft lip and palate patients after palatoplasty based on computed tomographic scanning and three dimensional data (2010)
  • Author(s): Hideto Saijo, et al
  • Journal Title: Scand J Plast Reconstr Surg Hand SURG Volume: 44(1) Pages: 21-25
  • Peer Reviewed
• [Journal Article] A bone harvesting method involving a surgical template prepared using a three-dimensional model (2010)
  • Author(s): Saijo H, et al.
  • Journal Title: Asian.J.Oral.Maxillofac.Surg Volume: 22 Pages: 20-22
  • Peer Reviewed
• [Journal Article] Metastasis of hepatocellular carcinoma into the mandible with radiographic findings mimicking a radicular cyst : a case report. (2010)
  • Author(s): Fujihara H, et al
  • Journal Title: J Endod. Volume: 36 Pages: 1593-1596
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 activity is important in craniofacial fracture repair. (2010)
  • Author(s): Chikazu D, et al.
  • Journal Title: Int J Oral Maxillofac Surg Volume: 40 Pages: 322-326
  • Peer Reviewed
• [Journal Article] Evaluation and analysis of bone formation at palate of cleft lip and palate patients after palatoplasty based on computed tomographic scanning and three dimensional data (2010)
  • Author(s): Hideto Saijo, et al.
  • Journal Title: Scand J Plast Reconstr Surg Hand Surg 44 Pages: 21-25
  • Peer Reviewed
• [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology (2009)
  • Author(s): Hideto Saijo, et al
  • Journal Title: J Artif Organs Volume: vol.12 Pages: 200-205
  • Peer Reviewed
• [Journal Article] An alternative method for correction of nasal deformity using ear cartilage for bilateral cleft nasal correction in school-age children (2009)
  • Author(s): Hideto Saijo, et al
  • Journal Title: Asian J Oral Maxillofac Surg Volume: 21 Pages: 109-13
  • Peer Reviewed
• [Journal Article] 舌下腺に発生した濾胞性リンパ腫の1例 (2009)
  • Author(s): 末永英之、西條英人、杉山円、森良之、飯野光喜、高戸毅
  • Journal Title: 日本口腔外科学会雑誌 Volume: 55(7) Pages: 373-377
  • NAID: 10027090861
  • Peer Reviewed
• [Journal Article] 口外法により下顎枝舌側部に再発したエナメル上皮腫を切除した1例 (2009)
  • Author(s): 近津大地、森良之、西條英人、藤原久子、飯野光喜、高戸毅
  • Journal Title: 日本口腔外科学会雑誌 Volume: 55 Pages: 241-245
  • NAID: 10027090393
  • Peer Reviewed
• [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology (2009)
  • Author(s): Hideto Saijo, et al.
  • Journal Title: J Artif Organs 12 Pages: 200-205
  • Peer Reviewed
• [Journal Article] An alternative method for correction of nasal deformity using ear cartilage for bilateral cleft nasal correction in school-age children (2009)
  • Author(s): Hideto Saijo, et al.
  • Journal Title: Asian.J.Oral.Maxillofac 21 Pages: 109-113
  • Peer Reviewed
• [Presentation] 吸収性メッシュトレーとPCBMを用いた斜顔裂二次形成術の経験 (2011)
  • Author(s): 西條英人, 他
  • Organizer: 第35回日本口蓋裂学会総会・学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2011-05-25
• [Presentation] 吸収性メッシュトレーとPCBMを用いた斜顔裂二次形成術の経験 (2011)
  • Author(s): 西條英人、他
  • Organizer: 第35回日本口蓋裂学会総会・学術集会
  • Place of Presentation: 朱鷺メッセ新潟
• [Presentation] 口唇口蓋裂患者における二段階上顎骨延長・下顎後方移動術を用いた外科的矯正治療の治療結果 (2010)
  • Author(s): 須佐美隆史,森良之,大久保和美,長濱浩平,西條英人,高戸毅
  • Organizer: 第28回日本頭蓋顎顔面外科学会学術集会
  • Place of Presentation: 京都大学吉田キャンパス百周年時計台記念館京都
  • Year and Date: 2010-10-29
• [Presentation] 下顎枝後方切開を用いた下顎骨関節突起基部骨折の治療経験 (2010)
  • Author(s): 古賀陽子,阿部雅修,菅野勇樹,斉藤健太郎,西條英人,近津大地,飯野光喜,森良之,高戸毅
  • Organizer: 第55回日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2010-10-18
• [Presentation] 粘膜下口蓋裂の診断基準に関する検討-第1報:骨欠損に関して- (2010)
  • Author(s): 西條英人、他
  • Organizer: 第34回日本口蓋裂学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-28
• [Presentation] 粘膜下口蓋裂の診断基準に関する検討 (2010)
  • Author(s): 西條英人, ら
  • Organizer: 第34回日本口蓋裂学会総会
  • Place of Presentation: 北とぴあ(東京 北区)
  • Year and Date: 2010-05-28
• [Presentation] シンポジウム8「歯科領域の再生医療」顎骨の再生医療 (2010)
  • Author(s): 西條英人、他
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 確定診断が困難な下顎悪性歯原性腫瘍の1例 (2009)
  • Author(s): 阿部雅修,西條英人,飯野光喜,菅野勇樹,斎藤健太郎,近津大地,森良之,高戸毅
  • Organizer: 第188回日本口腔外科学会関東地方会
  • Place of Presentation: 東京慈恵会医科大学,東京
  • Year and Date: 2009-12-26
• [Presentation] チタンメッシュトレーによる上顎骨再建後にインプラントを用いて咬合回復を行なった1例 (2009)
  • Author(s): 齋藤健太郎,西條英人,菅野勇樹,杉山円,前田祐二郎,飯野光喜,高戸毅
  • Organizer: 第13回日本顎顔面インプラント学会総会・学術大会
  • Place of Presentation: アバンセ,佐賀
  • Year and Date: 2009-12-12
• [Presentation] Cyclooxygenase-2は膜性骨の骨折治癒におけるkey factorである (2009)
  • Author(s): 近津大地,藤川由美子,末永英之,杉山円,古賀陽子,阿部雅修,西條英人,森良之,飯野光喜,高戸毅
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌コンベンションセンター,北海道
  • Year and Date: 2009-10-11
• [Presentation] 口蓋裂、分葉舌、下顎下口唇重複体を伴った上顎体の1例 (2009)
  • Author(s): 前田祐二郎,近津大地,末永英之,杉山円,斉藤健太郎,西條英人,森良之,飯野光喜、高戸毅
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌コンベンションセンター,北海道
  • Year and Date: 2009-10-09
• [Presentation] 安心・安全施術のための術前診断と問題発生時のリカバリー法 (2009)
  • Author(s): 西條英人
  • Organizer: 第2回日本先進インプラント医療学会総会
  • Place of Presentation: 一橋記念講堂(東京都)
  • Year and Date: 2009-09-06
• [Book] 医師・歯科医師のための口腔診療必携 (2010)
  • Author(s): 西條英人, ら
  • Total Pages: 263
  • Publisher: 金原出版株式会社
• [Book] In vivo tissue engineeringによる下顎骨再建Series再生医学のいま-基礎研究から臨床への展開に向けて- (2009)
  • Author(s): 飯野光喜,森良之,近津大地,西條英人,大久保和美,市川直子,前田祐二郎,高戸毅
• [Book] 日本口腔外科学会雑誌(再建下顎におけるインプラント治療) (2009)
  • Author(s): 西條英人
  • Total Pages: 6
• [Book] In vivo tissue engineeringによる顎骨再建の実際「CLINICAL CALCIUM」 (2008)
  • Author(s): 飯野光喜、森良之、近津大地、西條英人、大久保和美、高戸毅
  • Publisher: UPDATE・Therapy
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~oralsurg/archive.html
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~oralsurg/archive.html
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~oralsurg/archive.html
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~oralsurg/archive.html