The elucidation of bone formation by PTH centering on G protein and its application to bone regeneration
| Project/Area Number |
21791973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAIJYO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 副甲状腺ホルモン / 骨形成 / G蛋白 / PTHシグナル / Gαs / Gαq / 骨代謝調節機構 / 骨形成促進剤の開発 |
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| Research Abstract |
The purpose of this study is to clarify regulatory mechanism of bone and cartilage metabolism by Gαs and Gαq signaling via PTH using TypeI collagen Cre ; Gαs-or Gαq-flox mice and TypeII collagen Cre ; Gαs-or Gαq-flox mice. In vitro, using constitutively active Gαs-or Gαq adenoviruses, we tried to clarify osteogenic and chondrogenic function via Gαs-or Gαq signaling.
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Report
(4 results)
Research Products
(35 results)
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[Presentation] Cyclooxygenase-2は膜性骨の骨折治癒におけるkey factorである2009
Author(s)
近津大地,藤川由美子,末永英之,杉山円,古賀陽子,阿部雅修,西條英人,森良之,飯野光喜,高戸毅
Organizer
第54回日本口腔外科学会総会
Place of Presentation
札幌コンベンションセンター,北海道
Year and Date
2009-10-11
Related Report
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