Development of high performance artificial bones for maxillofacial reconstruction

• Project/Area Number: 21791975
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tohoku University (2010-2011); The University of Tokyo (2009)
• Principal Investigator: IGAWA Kazuyo 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (90512111)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 口腔顎顔面再建外科学 / 再生医療 / 生体材料

Research Abstract

The ideal high performance artificial bone was developed by the fabrication of three-dimensional forms from tricalcium phosphate using a 3D inkjet printer incorporating the optimal design of pores to improve the mechanical properties and cell affinity, in conjunction with printing basic fibroblast growth factor on the pores to accelerate bone regeneration. This study indicated that printing bFGF on the pores of the three dimensional artificial bones stimulated the new bone formation in the beagle skull defects. It was suggested that the high performance artificial bone can become a new treatment modality for bone regeneration.

Research Products

• [Journal Article] Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants (2011)
  • Author(s): Choi S, Lee J, Igawa K, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N
  • Journal Title: J Vet Med Sci Volume: 73(12) Pages: 1547-1552
  • NAID: 130001032572
  • Peer Reviewed
• [Journal Article] Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs (2009)
  • Author(s): Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N
  • Journal Title: J Artif Organs Volume: 12(4) Pages: 274-277
  • NAID: 10027225593
  • Peer Reviewed
• [Presentation] Chin augmentation with inkjet-printed custom-made tricalcium phosphate implant (2010)
  • Author(s): Kazuyo Igawa
  • Organizer: European Association for Cranio-Maxillo-Facial Surgery
  • Place of Presentation: Bruges, Belgium
• [Presentation] Chin augmentation with inkjet-printed custom-made tricalcium phosphate implant. (2010)
  • Author(s): 井川和代
  • Organizer: European Association for Cranio-Maxillo-Facial Surgery
  • Place of Presentation: Bruges, Belgium
• [Presentation] 3次元有限要素モデルによるインクジェットプリンターを用いたカスタムメイド人工骨(IPCAB)の構造最適化 (2009)
  • Author(s): 井川和代
  • Organizer: 第54回日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌コンベンションセンター, 日本
  • Year and Date: 2009-10-09
• [Presentation] 3次元有限要素モデルによるインクジェットプリンターを用いたカスタムメイド人工骨(IPCAB)の構造最適化 (2009)
  • Author(s): 井川和代
  • Organizer: 第54回日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2009-10-09
• [Presentation] Finite element analysis of the chin augmentation using custom-made tricalcium phosphate implant (2009)
  • Author(s): 井川和代
  • Organizer: 11^<th> ESPRAS Congress
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2009-09-26
• [Presentation] Finite element analysis of the chin augmentation using inkjet-printed custom-made tricalcium phosphate implants (2009)
  • Author(s): Kazuyo Igawa
  • Organizer: ESPRAS
  • Place of Presentation: Rhodes, Greece