| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
We investigated Myeloid Derived Suppressor Cells induced in tumor-bearing mice after injection with transplantable oral squamous cell carcinoma, and clarified that GM-CSF is needed to maintain these cells. But, there is difference in quantity of these cells among oral cancer patients unlike mouse model using murine oral cancer cell line producing GM-CSF, which might be depending on quantity of GM-CSF produced by human oral cancer, because there is difference in GM-CSF production individually. The analysis of the relationship between these cells and GM-CSF production is currently under investigation, concomitantly with the analysis of expression levels of B7-H3 on tumor cells in oral cancer patients.
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