The role of Hemokinin-1 in neuropathic pain

• Project/Area Number: 21791980
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MATSUMURA Tomoka Tokyo Medical and Dental University, 歯学部附属病院, 医員 (40527066)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 歯科麻酔学 / タキキニン / ヘモキニン-1 / ミクログリア / 神経因性疼痛

Research Abstract

We investigated the role of hemokinin-1 (HK-1), a new member of the tachykinin family, in neuropathic pain. HK-1 is encoded TAC4 gene. In the present study, TAC4 mRNA expression was increased in the cultured microgrial cells which were activated by LPS. That suggests a specific contribution of HK-1 to neuropathic pain.