The relationship of intraepithelial blood vessels and NBI system in oral borderline malignancies.

• Project/Area Number: 21791981
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Niigata University
• Principal Investigator: FUNAYAMA Akinori Niigata University, 医歯学総合病院, 医員 (80529686)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 臨床腫瘍学 / 口腔粘膜悪性境界病変 / 上皮内癌 / 上皮内血管 / NBI

Research Abstract

Blood capillary vessels within the epithelial zone(IEBVs) of oral borderline malignancies including epithelial dysplasia and carcinoma in-situ(CIS) were examined by immunohistochemistry for CD31 and type IV collagen. IEBVs increased in number significantly in CIS. It was revealed that narrow band imaging(NBI), that is established to visualize abnormal microvascular patterns was a effective tool for differential diagnosis of oral borderline malignancies and decision of a adequate safety margin.