The role of regulatory T cells induced by CCL22+ IDO+ dendritic cells in the oral cancer.

Research Project

Project/Area Number	21791984
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	WATANABE Yoshiko Hamamatsu University School of Medicine, 医学部, 助教 (10444358)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	口腔扁平上皮癌 / 免疫担当細胞 / ケモカイン / 扁平上皮癌 / 口腔 / 免疫細胞 / 遊走細胞 / 細胞遊走
Research Abstract	We examined the infiltration of regulatory T cells in the oral squamous cell carcinoma. CD4+CD25+CD69+Foxp3+ regulatory T cells abundantly infiltrated to the cancer nest. We revealed that although total Tregs had no significant impact on survival, higher stromal CCR4+ (one of the Th2 chemokine receptors) Treg number was associated with a reduced survival time.

Report

(3 results)