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Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family

Research Project

Project/Area Number 21791985
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionNagoya University

Principal Investigator

KATAGIRI Wataru  Nagoya University, 医学系研究科, 助教 (10437030)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsWntシグナル / 骨再生医療 / 幹細胞 / MSC / sFRP-3 / 未分化間葉系幹細胞 / 組織工学 / 細胞培養
Research Abstract

Recently it has been revealed that Wnt signaling pathway regulates the osteoblastic differentiation of human mesenchymal stem cells (hMSCs). We used sFRP-3, the antagonist of Wnt, to regulate this signaling and investigated the effect on osteoblastic differentiation of hMSCs in vitro and in vivo. It was revealed that the addition of sFRP-3 showed early differentiation and mineralization of hMSCs, and also showed early bone regeneration in animal model. These findings indicated the possibility of novel bone regenerative medicine using sFRP-3.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Regulation of the canonical Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration2010

    • Author(s)
      Katagiri W, Yamada Y, Nakamura S, Ito K, Hara K, Hibi H, Ueda M.
    • Journal Title

      Oral Science International 7

      Pages: 37-46

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells2010

    • Author(s)
      Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M, Yura Y.
    • Journal Title

      International Journal of Oncology 37

      Pages: 1095-1103

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the canonical Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration2010

    • Author(s)
      Katagiri W, Yamada Y, Nakamura S, Ito K, Hara K, Hibi H, Ueda M
    • Journal Title

      Oral Science International

      Volume: 7 Pages: 37-46

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the Wnt-B-catenin pathway in invasion and migration of oral squamous carcinoma cells2010

    • Author(s)
      Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M, Yura Y
    • Journal Title

      International Journal of Oncology

      Volume: 37 Pages: 1095-1103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration2010

    • Author(s)
      Katagiri W
    • Journal Title

      Oral Science International (In press)

    • NAID

      10027680495

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp2009

    • Author(s)
      Nakamura S
    • Journal Title

      Journal of Endodontics 35

      Pages: 1536-1542

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯髄幹細胞による再生医療を用いたインプラント治療への応用 -乳歯、永久歯歯髄幹細胞による骨再生パラダイムシフト-2009

    • Author(s)
      山田陽一
    • Organizer
      第39回日本口腔インプラント学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト乳歯歯髄由来幹細胞の細胞特性の検討Wnt/β-カテニン経路の関連2009

    • Author(s)
      片桐渉
    • Organizer
      第54回日本口腔外科学会総会・学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳歯・永久歯歯髄幹細胞による顎顔面領域再生への可能性2009

    • Author(s)
      山田陽一
    • Organizer
      第54回日本口腔外科学会総会・学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization and possibility of bone regeneration for dental implant using dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) as novel stem cell orgin2009

    • Author(s)
      Nakamura S
    • Organizer
      18^<th> Annual Scientific Meeting European Association for Osseointegration
    • Place of Presentation
      Monaco
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳歯および永久歯歯髄細胞の遺伝子発現プロファイルの比較検討2009

    • Author(s)
      中村さやか
    • Organizer
      第130回日本歯科保存学会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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