| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We reported that salivary glands (SMG) are necessary for the induction and maintenance in oral immunization. But it is unknown that what kinds of salivary factors affected in those response. The SMG produces significant quantities of nerve growth factor (NGF), and epidermal growth factor (EGF), which are secreted into the saliva and might affect immune response on the mucosal tissues and nerve endings in the gastrointestinal tract. In the present study, we demonstrated the role of salivary NGF for immune response in the gastrointestinal tract, using sialoadenectmised mice.
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