Expression and functional analysis of TPX2 gene in human salivary gland tumors

• Project/Area Number: 21791998
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SHIGEISHI Hideo Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (90397943)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 細胞周期 / 悪性腫瘍 / 紡錘体形成

Research Abstract

The mRNA expression of TPX2 and RHAMM was increased in malignant salivary gland carcinomas compared with that in normal salivary glands. Moreover, TPX2 and RHAMM expression was observed in the mitotic spindle at the mitotic stage of cell cycle. RHAMM expression was increased at the M phase of cell cycle. These results suggest that TPX2 and RHAMM play a significant role in growth of the tumor cells.

Research Products

• [Journal Article] RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR. (2011)
  • Author(s): Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N.
  • Journal Title: Lab Invest in press
  • Peer Reviewed
• [Journal Article] RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR. (2011)
  • Author(s): Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N.
  • Journal Title: Laboratory Investigation Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] CX3CL1 expression induced by Candida albicans in oral fibroblasts. (2010)
  • Author(s): Ohta K, Nishi H, Fukui A, Shigeishi H, Takechi M, Kamata N.
  • Journal Title: FEMS Immunol Med Microbiol. Nov;60(2) Pages: 179-185
  • Peer Reviewed
• [Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and-unstained areas. (2010)
  • Author(s): Ohta K, Ogawa I, Ono S, Taki M, Mizuta K, Miyauchi M, Takechi M, Shigeishi H, Takata T, Kamata N.
  • Journal Title: Oncol Rep. 24(1) Pages: 9-14
  • Peer Reviewed
• [Journal Article] Amphiregulin induces proliferative activities in osseous dysplasia. (2009)
  • Author(s): Shigeishi H, Yamaguchi S, Mizuta K, Nakakuki K, Fujimoto S, Amagasa T, Kamata N.
  • Journal Title: J Dent Res 88(6) Pages: 563-568
  • Peer Reviewed
• [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (2009)
  • Author(s): Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, Higashikawa K, Kamata N.
  • Journal Title: Int J Oncol 34(6) Pages: 1565-1571
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. (2009)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N.
  • Journal Title: Int J Cancer. 124(12) Pages: 2837-2844
  • Peer Reviewed
• [Journal Article] Expression of TPX2 in salivary gland carcinomas. (2009)
  • Author(s): Shigeishi H, Ohta K, Hiraoka M, Fujimoto S, Minami M, Higashikawa K, Kamata N.
  • Journal Title: Oncol Rep 21(2) Pages: 341-344
  • Peer Reviewed
• [Journal Article] Amphiregulin induces proliferative activities in osseous dysplasia. (2009)
  • Author(s): Shigeishi H
  • Journal Title: Journal of Dental Research 88(6) Pages: 563-568
  • Peer Reviewed
• [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (2009)
  • Author(s): Shigeishi H
  • Journal Title: International Journal of Oncology 34(6) Pages: 1565-1571
  • Peer Reviewed
• [Presentation] RHAMM induces proliferative activities of cementifying fibroma cells. (2010)
  • Author(s): Hiroko Hatano, Hideo Shigeishi, Yasusei Kudo, Takashi Takata, Nobuyuki Kamata.
  • Organizer: The 88th General Session of the IADR in Barcelona
  • Place of Presentation: Spain
  • Year and Date: 2010-07-17
• [Presentation] PGE2-induced expression of NR4A2 confers anti-apototic capability. (2010)
  • Author(s): Hideo Shigeishi, Koichiro Higashikawa, Hiroko Hatano, Kei Tobiume, Nobuyuki Kamata.
  • Organizer: The 88th General Session of the IADR in Barcelona
  • Place of Presentation: Spain
  • Year and Date: 2010-07-16
• [Presentation] PGE2-induced expression of NR4A2 confers anti-apoptotic capability. (2010)
  • Author(s): Hideo Shigeishi
  • Organizer: The 88th General Session of the International Association for Dental Research
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] ヒト口腔扁平上皮癌におけるNR4A2の発現および機能解析 (2010)
  • Author(s): 重石英生, 東川晃一郎, 波多野寛子, 田中扶美, 小野重弘, 鎌田伸之
  • Organizer: 第64回日本口腔科学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-24
• [Remarks] ホームページ等