The participation of micro RNA acquiring the ability with high-invasiveness via Epithelial-mesenchymal Transition in squamous cell carcinoma

• Project/Area Number: 21791999
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: ONO Shigehiro Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (70379882)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 臨床腫瘍学 / 口腔扁平上皮癌 / 遺伝子 / 抗癌剤 / 上皮・間葉移行 / 浸潤・転移 / 口腔癌 / 癌の浸潤・転移 / 転写因子 / 扁平上皮癌

Research Abstract

The aim of this study was to find sigunificant microRNAs for acquiring high-invasiveness in SCC cell lines using microRNA microarrays. As a results of the investigation, I have identified 9 microRNAs related infiltration. These results suggest that identified microRNAs in this research will be candidates of a cancer therapy target.

Research Products

• [Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and-unstained areas. (2010)
  • Author(s): Ohta K, Ogawa I, Ono S, Taki M, Mizuta K, Miyauchi M, Takechi M, Shigeishi H, Takata T, Kamata N.
  • Journal Title: Oncol Rep. 24(1) Pages: 9-14
  • Peer Reviewed
• [Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas. (2010)
  • Author(s): Ohta K, Ogawa I, Ono S, Taki M, Mizuta K, Miyauchi M, Takechi M, Shigeishi H, Takata T, Kamata N.
  • Journal Title: Oncol Rep. Volume: 24(1) Pages: 9-14
  • Peer Reviewed
• [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (2009)
  • Author(s): Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, Higashikawa K, Kamata N.
  • Journal Title: Int J Oncol. 34(6) Pages: 1565-1571
  • Peer Reviewed
• [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. (2009)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N.
  • Journal Title: Int J Cancer. 124(12) Pages: 2837-2844
  • Peer Reviewed
• [Presentation] A snail target gene product Cyr61 regulates the invasiveness of squamous cell carcinoma. (2010)
  • Author(s): Tanaka F, Higashikawa K, Tobiume K, Ono S, Shigeishi H, Okui G, Kamata N
  • Organizer: 第69回日本癌学会・学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] ヒト口腔扁平上皮癌におけるNR4A2の発現および機能解析 (2010)
  • Author(s): 重石英生, 東川晃一郎, 波多野寛子, 田中扶美, 小野重弘, 鎌田伸之
  • Organizer: 第64回日本口腔科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25
• [Presentation] Snailが制御する口腔扁平上皮癌細胞における浸潤能を付与する分泌タンパク (2010)
  • Author(s): 田中扶美, 東川晃一郎, 奥井岳, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第43回広島大学歯学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-06-12
• [Presentation] EMT型口腔扁平上皮癌細胞におけるgamma-secretase inhibitor抵抗性の解析 (2009)
  • Author(s): 東川晃一郎, 田中扶美, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 口腔扁平上皮癌細胞における高度浸潤能獲得機構の解析 (2009)
  • Author(s): 田中扶美, 東川晃一郎, 重石英生, 小野重弘, 鎌田伸之
  • Organizer: 第54回(社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] A Snail-induced secretory protein associated with the invasiveness of squamous cell carcinoma (2009)
  • Author(s): Tanaka F, Higashikawa K, Tobiume K, Ono S, Shigeishi H, Kamata N
  • Organizer: 第68回日本癌学会・学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03