Fabrication of the high functional bone replacement apatite cement with drug delivery control capacity

• Project/Area Number: 21792000
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TAKECHI Masaaki Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 (00304535)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アパタイト / 抗菌薬 / 骨置換 / 骨芽細胞 / 細菌 / セメント / 破骨細胞 / リモデリング

Research Abstract

We developed a high functional apatite cement which have improved osteoconduction and release antibiotic continuously. Also, after we fabricated jaw osteomyelitis model using adult rabbit, we evaluated antibacterial effect on apatite cement containing antibiotic histologically. As a result, jaw osteomyelitis perfectly recovered by using apatite cement containing antibiotic. We concluded that apatite cement containing antibiotic was a good candidate for potential use as a DDS carrier that may be useful in jaw osteomyelitis treatment.

Research Products

• [Journal Article] CX3CL1 expression induced by Candida albicans in oral fibroblasts. (2010)
  • Author(s): Ohta, K., Nishi, H, Fukui, A, Shigeishi, H, Takechi, M, Kamata, N.
  • Journal Title: FEMS.Immunol.Med.Microbiol. 60(2) Pages: 179-185
  • Peer Reviewed
• [Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and-unstained areas. (2010)
  • Author(s): Ohta, K, Ogawa, I, Ono, S, Taki, M, Mizuta, K, Miyauchi, M, Takechi, M, Shigeishi, H, Takata, T., Kamata, N.
  • Journal Title: Oncol Rep. 24(1) Pages: 9-14
  • Peer Reviewed
• [Journal Article] Influence of factors related to implant stability detected by wireless resonance frequency analysis device. (2010)
  • Author(s): Ohta, K., Takechi, M, Minami, M, Shigeishi, H., Hiraoka, M, Nishimura M., Kamata, N.
  • Journal Title: J Oral.Rehabil. 37(2) Pages: 131-137
  • Peer Reviewed
• [Journal Article] CX3CL1 expression induced by Candida albicans in oral fibroblasts. FEMS. (2010)
  • Author(s): Kouji Ohta, Masaaki Takechi
  • Journal Title: Immunol.Med.Microbiol. Volume: 60 Pages: 179-185
  • Peer Reviewed
• [Journal Article] Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas (2010)
  • Author(s): Kouji Ohta, Masaaki Takechi
  • Journal Title: Oncol Rep Volume: 24 Pages: 9-14
  • Peer Reviewed
• [Journal Article] Influence of factors related to implant stability detected by wireless resonance frequency analysis device (2010)
  • Author(s): Kouji Ohta, Masaaki Takechi
  • Journal Title: J Oral.Rehabil. Volume: 37 Pages: 131-137
  • Peer Reviewed
• [Journal Article] Effect of TGF-β1 on differentiation and mineralization of osteoblasts in interconnective porous calcium hydroxyapatite ceramics. (2009)
  • Author(s): Hiraoka, M., Takechi, M., Minami, M., Ohta, K., Kamata, N.
  • Journal Title: Archives of Bioceramics Research. 9 Pages: 303-306
  • Peer Reviewed
• [Journal Article] Effect of TGF-β1 on differentiation and mineralization of osteoblasts in intereonnective porous calcium hydroxyapatite ceramics. (2009)
  • Author(s): Misato Hiraoka, Masaaki Takechi
  • Journal Title: Archives of Bioceramics Research. 9 Pages: 303-306
  • Peer Reviewed
• [Presentation] GM含有α-TCP/ACの顎骨骨髄炎への応用に関する基礎的研究-基本物性と骨形成評価について- (2010)
  • Author(s): 二宮嘉昭、武知正晃、太田耕司、南正彦、多田美里、太田彰、湯浅哲也、石川邦夫、鎌田伸之
  • Organizer: 第32回日本バイオマテリアル学会
  • Place of Presentation: 広島
  • Year and Date: 2010-11-30
• [Presentation] GM含有α-TCP/AC硬化体の顎骨骨髄炎への応用に関する基礎的研究-基本物性と骨形成能について- (2009)
  • Author(s): 二宮嘉昭、武知正晃、太田耕司、南正彦、平岡美里、太田彰、湯浅哲也、石川邦夫、鎌田伸之
  • Organizer: 第31回日本バイオマテリアル学会
  • Place of Presentation: 京都テルサ(京都)
  • Year and Date: 2009-11-17
• [Presentation] GM含有α-TCP/AC硬化体の顎骨骨髄炎への応用に関する基礎的研究-基本物性と骨形成能について- (2009)
  • Author(s): 二宮嘉昭, 武知正晃
  • Organizer: 第31回 日本バイオマテリアル学会
  • Place of Presentation: 京都テルサ(京都)
  • Year and Date: 2009-11-17
• [Remarks] ホームページ等