Development of oral cancer therapy using anti cancer drug and siRNA against MSF, a novel angiogenic factor.

• Project/Area Number: 21792005
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: OOE Gou The University of Tokushima, 病院, 助教 (60432762)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 臨床腫瘍学 / Migration Stimulating Factor / 口腔癌 / 浸潤 / 血管新生 / Migration Stmulating Factor

Research Abstract

Migration Stimulating Factor (MSF) enhanced cancer progression by stimulating of cancer migration and angiogenic. In vitro study, combination therapy of siRNA against MSF (MSF siRNA) and anti cancer drug demonstrated additive effect. In vivo study, treatment with MSF siRNA only or combination therapy of MSF siRNA and anti cancer drug showed anti cancer effect against nudemice bearing B88, oral SCC.

Research Products

• [Journal Article] Migration-stimulating factor as a novel biomarker in salivary gland tumours. (2011)
  • Author(s): Aljorani LE, Bankfalvi A, Carey FA, Harada K, Ohe G, Jones SJ, Ellis IR, Schor SL, Schor AM.
  • Journal Title: J Oral Pathol Med.
  • Peer Reviewed
• [Journal Article] Migration-stimulating factor as a novel biomarker in salivary gland tumours (2011)
  • Author(s): Aljorani LE
  • Journal Title: J Oral Pathol Med
  • Peer Reviewed
• [Journal Article] Multi-functional modukation of IGD motogenic potential in MSF (migration stimulating factor). (2010)
  • Author(s): Ellis IR, Jones SJ,Staunton D, Vakonakis I, Norman DG, PottsJR, Milner CM, Meenan NA, Raibaud S, Ohe G,Schor AM, Schor SL.
  • Journal Title: Exp Cell Res 316 Pages: 2465-2476
  • Peer Reviewed
• [Journal Article] Migration Stimulating Factor (MSF)promotes fibroblast migration byinhibiting AKT. (2010)
  • Author(s): Ellis IR, Jones SJ, LindsayY, Ohe G, Schor AM, Schor SL, Leslie NR.
  • Journal Title: Cell Signal. 22 Pages: 1655-1659
  • Peer Reviewed
• [Journal Article] Migration Stimulating Factor (MSF) promotes fibroblast migration by in hibiting AKT (2010)
  • Author(s): Ellis IR
  • Journal Title: Cell Signal Volume: 22 Pages: 1655-1659
  • Peer Reviewed
• [Journal Article] Multi-factorial modulation of IGD motogenic potential in MSF (migration stimulating factor). (2010)
  • Author(s): Ellis IR
  • Journal Title: Exp Cell Res Volume: 22 Pages: 2465-2476
  • Peer Reviewed
• [Remarks] ホームページ等