Development of combined therapy of oral cancer of which molecular target survivin and NF-・B
| Project/Area Number |
21792006
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
TAKAMARU Natsumi The University of Tokushima, 病院, 助教 (40513031)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | survivin / NF-・B / 分子標的薬 / NF-κB |
|---|
| Research Abstract |
[Result] Rate of survivin expression in oral squamous cell carcinoma patients was 88%. localization of survivin is a positive-type nucleus and cytoplasm, cytoplasm negative nucleus-positive type and negative-type nucleus and the cytoplasm, was classified into three groups. Between the degree of differentiation and the expression of survivin in cancer was not associated, but showed a correlation between nuclear survivin expression in invasion style, Yamamoto-Kohama classification.
[Conclusion] Expression of survivin in oral squamous cell carcinoma and enhance its level of expression was suggested to be related to invasion style.
|
Report
(3 results)
Research Products
(3 results)
