Novel therapeutic strategy for salivary gland carcinoma targeting androgen receptor.
| Project/Area Number |
21792008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
YOSHIMURA Tomohide Kochi University, 教育研究部医療学系, 助教 (80452697)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 唾液腺癌 / ホルモン療法 / アンドロゲンレセプター / アンドロゲン / ステロイドホルモン |
|---|
| Research Abstract |
Androgen receptor(AR) is expressed in prostate carcinoma, and hormonal therapy has been commonly used. On the other hand, it is reported that salivary gland carcinomas express androgen receptor (AR), however little is known regarding its role in the salivary gland carcinoma. In this study, we investigate a possibility of hormonal therapy for salivary gland carcinoma. We evaluated the expression of androgen receptor in a salivary gland carcinoma tissues and salivary gland carcinoma cell lines. As a result of immunohistochemistry and western bolting, all salivary gland carcinoma tissues and salivary gland cell lines were negative for AR. So few salivary gland carcinoma are applicable for hormonal therapy.
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Report
(3 results)
Research Products
(11 results)
