Tumor dormancy therapy for the human adenoid cystic carcinoma

• Project/Area Number: 21792009
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: SUMIDA Tomoki Ehime University, 医学部附属病院, 講師 (50314951)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 腺様嚢胞癌 / ID1 / エストロゲンレセプター / アンドロゲンレセプター

Research Abstract

In this study, we confirmed that hormonal therapy and Id1 targeting therapy could reduce the growth and invasion of adenoid cystic carcinoma cells. These results indicate that this strategy has a potential for the tumor dormancy therapy for the human adenoid cystic carcinoma.

Research Products

• [Journal Article] Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral squamous cell carcinoma. (2011)
  • Author(s): Z Dong, F Wei, C Zhou, T sumida, H Hamakawa, Y Hu, S Liu.
  • Journal Title: Oral Oncol. 47(1) Pages: 27-32
  • Peer Reviewed
• [Journal Article] Silencing Id-1 inhibits lymphangiogenesis through down-regulati on of VEGF-C in oral squamous cell carcinoma. (2011)
  • Author(s): Z Dong, F Wei, C Zhou, T sumida, H Hamakawa, Y Hu, S Liu
  • Journal Title: Oral Oncology Volume: 47 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Overexpression of Id-1 Is Associated with Tumor Angiogenesis and Poor Clinical Outcome in Oral Squamous Cell Carcinoma. (2010)
  • Author(s): Z Dong, S Liu, C Zhou, T Sumida, H Hamakawa, Z Chena, P Liu, F Wei.
  • Journal Title: Oral Oncol. 46(3) Pages: 154-157
  • Peer Reviewed
• [Journal Article] 悪性唾液腺腫瘍におけるホルモン療法の可能性 (2010)
  • Author(s): 住田知樹、石川詔子、浜川裕之
  • Journal Title: 日本口腔組織培養学会誌 18(2) Pages: 13-18
  • Peer Reviewed
• [Journal Article] Overexpression of Id-1 Is Associated with Tumor Angiogenesis and Poor Clinical Outcome in Oral Squamous Cell Carcinoma. (2010)
  • Author(s): Z Dong, S Liu, C Zhou, T Sumida, H Hamakawa, Z Chena, P Liu, F Wei.
  • Journal Title: Oral Oncology Volume: 46 Pages: 154-157
  • Peer Reviewed
• [Journal Article] 悪性唾液腺腫瘍におけるホルモン療法の可能性 (2010)
  • Author(s): 住田知樹、石川詔子、浜川裕之
  • Journal Title: 日本口腔組織培養学会誌 Volume: 18 Pages: 13-18
  • Peer Reviewed
• [Presentation] 性ステロイドホルモンが腺様嚢胞癌細胞の運動能、接着に及ぼす影響に関する検討 (2010)
  • Author(s): 住田知樹、石川詔子、浜川知大、藤田陽平、西川由希子、中城公一、浜川裕之
  • Organizer: 日本口腔科学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-06-24
• [Presentation] 性ステロイドホルモンが腺様嚢胞癌細胞の運動能、接着に及ぼす影響に関する検討 (2010)
  • Author(s): 住田知樹、石川詔子、浜川知大、藤田陽平、西川由希子、中城公一、浜川裕之
  • Organizer: 日本口腔科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-24
• [Remarks] ホームページ等
  • URL: http://emedical.s317.xrea.com/contents/?cat=6