Elucidation of invasion mechanism using ameloblastoma cell line

• Project/Area Number: 21792012
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: NAKAO Yu 九州大学, 大学院・歯学研究院, 助教 (70457430)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: エナメル上皮腫 / 浸潤機構 / FGF / Shh / エナメル上皮種

Research Abstract

shh signaling was expressed in ameloblastoma tissues ana AM-1 cells. AM-1 cells were decreased cell proliferation by using cycropamine, which was inhibitor of shh signaling, In the future, inhabitation of shh signaling in ameloblastoma will become treatment strategy.