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The basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin.

Research Project

Project/Area Number 21792015
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionNagasaki University

Principal Investigator

YAMADA Shinichi  長崎大学, 病院, 講師 (50380853)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords口腔癌 / ゲルダナマイシン / 浸潤 / 転移
Research Abstract

I performed the basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin. I examined the several molecules, which were involved in the metastasis and invasion in oral squamous cell carcinoma. And, I revealed these molecules such asα-actinin-4, cortactin, and CRKII, were involved in the metastasis and invasion in oral squamous cell lines, respectively, and the possibility of the target of molecular target therapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2012

    • Author(s)
      Yamada S
    • Journal Title

      Cancer Letters

      Volume: 303 Issue: 2 Pages: 84-91

    • DOI

      10.1016/j.canlet.2011.01.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2011

    • Author(s)
      Yamada S, Yanamoto S, Kawasaki G, Rokutanda S, Yonezawa H, Kawakita A, Nemoto TK
    • Journal Title

      Cancer Lett

      Volume: 303(2) Pages: 84-91

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2011

    • Author(s)
      Shin-ichi Yamada, et al.
    • Journal Title

      Cancer Letters

      Volume: (in press 掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma2010

    • Author(s)
      Yamada S, Yanamoto S, Yoshida H, Yoshitomi I, Kawasaki G, Mizuno A, Nemoto TK
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 39(1) Pages: 61-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma2010

    • Author(s)
      Yamada S, Yanamoto S, Kawasaki G, Mizuno A, Nemoto TK
    • Journal Title

      Pathol Oncol Res

      Volume: 16(4) Pages: 523-31

    • Related Report
      2011 Final Research Report
  • [Journal Article] RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.2010

    • Author(s)
      Yamada S.
    • Journal Title

      Int J Oral Maxillofac Surg. 39

      Pages: 61-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Cortactin Increases Invasion Potential in Oral Squamous Cell Carcinoma.2010

    • Author(s)
      Yamada S.
    • Journal Title

      Pathol Oncol Res.

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblastoma in the maxilla : Report of a case.2009

    • Author(s)
      Yamada S.
    • Journal Title

      Oral Med Pathol 14

      Pages: 37-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌浸潤能におけるcortactin/CRK IIの発現の意義2011

    • Author(s)
      山田慎一
    • Organizer
      第65回日本口腔科学会総会学術集会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔扁平上皮癌浸潤能におけるシグナル伝達アダプター因子CRKの発現の意義について2010

    • Author(s)
      山田慎一, 他
    • Organizer
      第55回日本口腔外科学会総会・学術集会
    • Place of Presentation
      千葉県、幕張メッセ
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌浸潤能におけるシグナル伝達アダプター因子CRKの発現の意義(ポスター)2010

    • Author(s)
      山田慎一, 他
    • Organizer
      第55回(社)日本口腔外科学会総会学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるEMS1/cortactinの発現の意義2009

    • Author(s)
      山田慎一
    • Organizer
      第54回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるEMS1の発現の意義2009

    • Author(s)
      山田慎一, 他
    • Organizer
      第63回日本口腔科学会学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるEMS1/ cortactinの発現の意義(ポスター)2009

    • Author(s)
      山田慎一, 他
    • Organizer
      第54回(社)日本口腔外科学会総会・学術大会
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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