The basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin.
| Project/Area Number |
21792015
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 口腔癌 / ゲルダナマイシン / 浸潤 / 転移 |
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| Research Abstract |
I performed the basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin. I examined the several molecules, which were involved in the metastasis and invasion in oral squamous cell carcinoma. And, I revealed these molecules such asα-actinin-4, cortactin, and CRKII, were involved in the metastasis and invasion in oral squamous cell lines, respectively, and the possibility of the target of molecular target therapy.
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Report
(4 results)
Research Products
(14 results)
