Elucidation of mechanism underlying 5-FU resistance in oral cancer using genomic analysis and application to multimodal personalized medicine
Project/Area Number |
21792017
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Kumamoto University |
Principal Investigator |
NAKAYAMA Hideki Kumamoto University, 医学部附属病院, 助教 (70381001)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 臨床腫瘍学 / 抗癌剤耐性 / 口腔扁平上皮がん / 5-フルオロウラシル / アポトーシス / cIAP2 / 口腔扁平上皮癌 / TS |
Research Abstract |
In the present study, to identify novel molecules associated with the 5-FU resistance of OSCC, we established a 5-FU-resistant OSCC cell line over a 2-year period, and found that an overexpression of cIAP2 confers 5-FU resistance in the cells. Furthermore, an immunohistochemical analysis using OSCC patient tissue samples demonstrated that increased expression of cIAP2 resulted in enhanced resistance to 5-FU-based chemoradiotherapy and a poor prognosis.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma.2010
Author(s)
Nomura T, Murakami R, Toya R, Teshima K, Nakahara A, Hirai T, Hiraki A, Nakayama H, Yoshitake Y, Ota K, Obayashi T, Yamashita Y, Oya N, Shinohara M.
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Journal Title
Int J Radiat Oncol Biol Phys. 76(5)
Pages: 1347-1352
Related Report
Peer Reviewed
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[Journal Article] Radiation-induced parotid gland changes in oral cancer patients : correlation between parotid volume and saliva production.2010
Author(s)
Teshima K, Murakami R, Tomitaka E, Nomura T, Toya R, Hiraki A, Nakayama H, Hirai T, Shinohara M, Oya N, Yamashita Y.
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Journal Title
Jpn J Clin Oncol. 40(1)
Pages: 42-46
Related Report
Peer Reviewed
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[Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma.2010
Author(s)
Nomura T, Murakami R, Toya R, Teshima K, Nakahara A, Hirai T, Hiraki A, Nakayama H, Yoshitake Y, Ota K, Obayashi T, Yamashita Y, Oya N, Shinohara M
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Journal Title
Int J Radiat Oncol Biol Phys.
Volume: 76
Pages: 1347-52
Related Report
Peer Reviewed
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[Journal Article] Radiation-induced parotid gland changes in oral cancer patients : correlation between parotid volume and saliva production.2010
Author(s)
Teshima K, Murakami R, Tomitaka E, Nomura T, Toya R, Hiraki A, Nakayama H, Hirai T, Shinohara M, Oya N, Yamashita Y.
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Journal Title
Jpn J Clin Oncol.
Volume: 40
Pages: 42-6
Related Report
Peer Reviewed
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[Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma.2010
Author(s)
Nomura T, Murakami R, Toya R, Teshima K, Nakahara A, Hirai T, Hiraki A, Nakayama H, Yoshitake Y, Ota K, Obayashi T, Yamashita Y, Oya N, Shinohara M
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Journal Title
Int J Radiat Oncol Biol Phys. 76
Pages: 1347-1352
Related Report
Peer Reviewed
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[Journal Article] Periodontal Status And Prevotella Intermedia Antibody In Acute Coronary Syndrome.2009
Author(s)
Soejima H, Oe Y, Nakayama H, Matsuo K, Fukunaga T, Sugamura K, Kawano H, Sugiyama S, Shinohara M, Izumi Y, Ogawa H.
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Journal Title
Int J Cardiol. 137(3)
Pages: 304-306
Related Report
Peer Reviewed
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[Journal Article] Significant Association Between Score of Periodontal Disease and Coronary Artery Disease Heart and Vessels2009
Author(s)
Oe Y, Soejima H, Nakayama H, Fukunaga T, Sugamura K, Kawano H, Sugiyama S, Matsuo K, Shinohara M, Izumi Y, Ogawa H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.2009
Author(s)
Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.
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Journal Title
Clin Cancer Res. 15(17)
Pages: 5426-5434
Related Report
Peer Reviewed
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[Journal Article] Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.2009
Author(s)
Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.
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Journal Title
Clin Cancer Res. 15
Pages: 5426-5434
Related Report
Peer Reviewed
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[Presentation] TS and cIAP2 are up-regulated in 5-FU-resistant oral squamous cell carcinoma cells2010
Author(s)
Masashi Nagata, Hideki Nakayama, Yoshihiro Yoshitake, Daiki Fukuma, Takuya Tanaka, Ryoji Yoshida, Yasuo Takamune, Hidenao Ogi, Kenta Kawahara, Yoshihiro Nakagawa, Masanori Shinohara
Organizer
第69回日本癌学会
Place of Presentation
グランキューブ大阪
Related Report
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[Presentation] TS and cIAP2 are up-regulated in 5-FU-resistant oral squamous cells carcinoma cells2010
Author(s)
Hideki Nakayama, Masashi Nagata, Yoshihiro Yoshitake, Daiki Fukuma, Tak uya Tanaka, Ryoji Yoshida, Yasuo Takamu ne, Hidenao Ogi, Kenta Kawahara, Yoshih iro Nakagawa, Masanori Shinohara
Organizer
第51回大韓口腔顎顔面外科学会
Place of Presentation
韓国 清州 ラマダプラザ清州ホテル
Related Report
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[Presentation] TS and cIAP2 are up-regulated in 5-FU-resistant oral squamous cell carcinoma cells2010
Author(s)
Hideki Nakayama, Masashi Nagata, Yoshihiro Yoshitake, Daiki Fukuma, Takuya Tanaka, Ryoji Yoshida, Yasuo Takamune, Hidenao Ogi, Kenta Kawahara, Yoshihiro Nakagawa, Masanori Shinohara
Organizer
第51回大韓口腔顎顔面外科学会
Place of Presentation
韓国清州ラマダプラザ清州ホテル
Related Report
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[Presentation] TS and cIAP2 are up-regulated in 5-FU-resistant oral squamous cell carcinoma cells2010
Author(s)
Masashi Nagata, Hideki Nakayama, Yoshihiro Yoshitake, Daiki Fukuma, Takuya Tanaka, Ryoji Yoshida, Yasuo Takamune, Hidenao Ogi, Kenta Kawahara, Yoshihiro Nakagawa, Masanori Shinohara
Organizer
第69回日本癌学会
Place of Presentation
大阪大阪国際会議場・リーガロイヤルホテル
Related Report
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[Presentation] 5-フルオロウラシル耐性口腔扁平上皮癌細胞の樹立とその細胞特性(Establishmentand characterization of 5-fluorouracil-resistant oral squamouscell carcinoma cell)2009
Author(s)
永田将士, 中山秀樹, 吉武義泰, 田中拓也, 吉田遼司, 福間大喜, 高宗康隆, 尾木秀直, 太田和俊, 平木昭光, 大林武久, 篠原正徳
Organizer
第68回日本癌学会
Place of Presentation
パシフィコ横浜
Related Report
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[Presentation] 5-フルオロウラシル耐性口腔扁平上皮癌細胞の樹立とその細胞特性(Establishment and characterization of 5-fluorouracil-resistant oral squamous cell carcinoma cell)2009
Author(s)
永田将士, 中山秀樹, 吉武義泰, 田中拓也, 吉田遼司, 福間大喜, 高宗康隆, 尾木秀直, 太田和俊, 平木昭光, 大林武久, 篠原正徳
Organizer
第68回日本癌学会総会
Place of Presentation
パシフィコ横浜(神奈川)
Related Report
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