| Project/Area Number |
21792020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
HAMADA Tomofumi 鹿児島大学, 医学部・歯学部附属病院, 助教 (00444894)
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| Research Collaborator |
YAMADA Norishige Cincinnati Children's Hospital Medical Center
NAGATA Satoshi 鹿児島大学, 大学院・医歯学総合研究科顎顔面疾患制御学分野
WAKAMATSU Tsunenobu 鹿児島大学, 大学院・医歯学総合研究科顎顔面疾患制御学分野
NOMURA Masahiro 鹿児島大学, 大学院・医歯学総合研究科顎顔面疾患制御学分野
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MUC1 / 口腔癌 / 予後規定因子 / 選択的スプライシング / 膜型ムチン / 転移 / MUC4 / スプライシング / スプライシング異常 / スプライシングバリアント / 予後因子 / 生存率 / 免疫組織化学的染色 |
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| Research Abstract |
The goal of this study was to detect alternative splicing of MUC1 mucin in oral squamous cell carcinoma and to evaluate its relationship with clinicopathological factors. First, we investigate the expression level of membranous mucin in the resected tumor samples by immunohistochemistry and found that aberrant expression MUC1 and MUC4 was an independent prognostic factor indicating poor prognosis in patients with OSCC. Next, we have started to evaluate the expression level of each splicing variant of MUC1, using the specimen from surgically resected oral squamous cell carcinoma. The expression level and proportion of MUC1 splicing variants showed a huge variety in each specimen.
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