Analysis of the role of transcription factor in the formation of tumor microvassel in oral cancer
| Project/Area Number |
21792022
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
OGI Kazuhiro Sapporo Medical University, 医学部, 助教 (40433114)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | がん微小環境 / HIF1 / NF-kappaB / 転写因子 / 口腔癌 / NF-kappa B / HIF-1 alpha / メチル化阻害薬 / 血管新生因子 / CHFR / NF-kB |
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| Research Abstract |
Hypoxia in tumor occurs in the majority of tumors, promoting angiogenesis, metastasis and resistance to chemotherapy. Although hypoxia seems to activate several cellular molecules and pathways, the overall molecular mechanism remains unknown. We performed HIF1 and NF-kappaB regulated cDNA plate array with oral squamous cell carcinoma under hypoxia and normoxia. We obtained a plate based array data for profiling 23 HIF-regulated genes and 23 NF-kappaB-regulated genes. There are some difference among oral squamous cell carcinoma.
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Report
(3 results)
Research Products
(6 results)
