Functional analysis of MIA, which is the novel lymphangiogenic marker of oral cancer

• Project/Area Number: 21792023
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nara Medical University
• Principal Investigator: SASAHIRA Tomonori Nara Medical University, 医学部, 助教 (90405374)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 口腔癌 / MIA / 血管新生 / リンパ管新生 / 口腔扁平上皮癌 / リンパ節転移 / MIA gene family / 予後

Research Abstract

We examined the role of MIA in oral cancer. We clarified MIA involves tumor growth, invasion, and apoptosis-resistant in oral squamous cell carcinoma. We also found MIA accelerates angiogenesis and lymphangiogenesis by induction of VEGF-A, VEGF-C, and VEGF-D and MIA is poor prognostic factor in oral cancer. These results suggested that MIA is a useful diagnostic and therapeutic target of oral cancer.

Research Products

• [Journal Article] Downregulation of runt-related transcription factor 3 (RUNX3) associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland (2011)
  • Author(s): Sasahira T, Kurihara M, Yamamoto K, Bhawal UK, Kirita T, Kuniyasu H.
  • Journal Title: Cancer Sci 102(2) Pages: 92-97
  • Peer Reviewed
• [Journal Article] HMGB1 attenuates anti-metastatic defence of the lymph nodes in colorectal cancer (2010)
  • Author(s): Moriwaka Y, Luo Y, Ohmori H, Fujii K, Tatsumoto N, Sasahira T, Kuniyasu H
  • Journal Title: Pathobiology 77(1) Pages: 17-23
  • Peer Reviewed
• [Journal Article] MIA-dependent angiogenesis and lymphangiogenesis are closely associated with progression, nodal metastasis and poor prognosis in tongue squamous cell carcinoma (2010)
  • Author(s): Sasahira T, Kirita T, Kurihara M, Yamamoto K, Bhawal UK, Bosserhoff AK, Kuniyasu H
  • Journal Title: Eur J Cancer 46(12) Pages: 2285-2294
  • Peer Reviewed
• [Journal Article] HMGB1 attenuates anti-metastatic defence of the lymph nodes in colorectal cancer (2010)
  • Author(s): Moriwaka Y
  • Journal Title: Pathobiology Volume: 77 Pages: 17-23
  • Peer Reviewed
• [Journal Article] MIA-dependent angiogenesis and lymphangiogenesis are closely associated with progression, nodal metastasis and poor prognosis in tongue squamous cell carcinoma (2010)
  • Author(s): Sasahira T
  • Journal Title: Eur J Cancer Volume: 46 Pages: 2285-2294
  • Peer Reviewed
• [Journal Article] Downregulation of runt-related transcription factor 3 (RUNX3) associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland (2010)
  • Author(s): Sasahira T
  • Journal Title: Cancer Sci Volume: 102 Pages: 492-497
  • Peer Reviewed
• [Journal Article] 頭頸部癌におけるリンパ管新生 (2009)
  • Author(s): 笹平智則
  • Journal Title: 奈良医学雑誌 60巻 Pages: 85-92
  • NAID: 120004973473
  • Peer Reviewed
• [Journal Article] 頭頸部癌におけるリンパ管新生 (2009)
  • Author(s): 笹平智則
  • Journal Title: 奈良医学雑誌 60 Pages: 85-92
  • NAID: 120004973473
  • Peer Reviewed
• [Presentation] MIA3は口腔扁平上皮癌の脈管新生を誘導する (2010)
  • Author(s): 笹平智則、栗原 都、山本一彦、バワール・ウジャール、桐田忠昭、國安弘基
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-18
• [Presentation] MIA3は口腔扁平上皮癌の脈管新生を誘導する (2010)
  • Author(s): 笹平智則
  • Organizer: 第21回日本消化器癌発生学会総会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-18
• [Presentation] 口腔癌におけるMIA3の役割 (2010)
  • Author(s): 笹平智則、栗原都、山本一彦、バワール・ウジャール、桐田忠昭、國安弘基
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 口腔扁平上皮癌におけるMIA2の発現 (2010)
  • Author(s): 栗原都、笹平智則、山本一彦、桐田忠昭、國安弘基
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 口腔癌におけるMIA3の役割 (2010)
  • Author(s): 笹平智則、栗原都、山本一彦、バワール・ウジャール、桐田忠昭、國安弘基
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-29
• [Presentation] 口腔扁平上皮癌におけるMIA2の発現 (2010)
  • Author(s): 栗原都、笹平智則、山本一彦、桐田忠昭、國安弘基
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-29
• [Presentation] 口腔扁平上皮癌におけるMIA2の発現 (2009)
  • Author(s): 栗原都、笹平智則、山本一彦、桐田忠昭、國安弘基
  • Organizer: 第20回日本消化器癌発生学会総会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-26
• [Presentation] 口腔扁平上皮癌におけるMIA2の発現 (2009)
  • Author(s): 笹平智則, ほか4名
  • Organizer: 第20回日本消化器癌発生学会総会
  • Place of Presentation: オリエンタルホテル広島
  • Year and Date: 2009-11-26
• [Presentation] 口腔癌のリンパ管新生・リンパ節転移へのMIAの関与 (2009)
  • Author(s): 笹平智則、栗原都、山本一彦、桐田忠昭、國安弘基
  • Organizer: 第18回日本がん転移学会総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-07-23
• [Presentation] 口腔癌のリンパ管新生・リンパ節転移へのMLAの関与 (2009)
  • Author(s): 笹平智則, ほか5名
  • Organizer: 第18回日本がん転移学会総会
  • Place of Presentation: 旭川グランドホテル
  • Year and Date: 2009-07-23
• [Book] Recent Advances in Metastasis of Gastrointestinal Cancers (2010)
  • Author(s): Sasahira T, Kuniyasu H.
  • Publisher: Transworld Research Network
• [Book] Recent Advances in Metastasis of Gastrointestinal Cancers (2010)
  • Author(s): Sasahira T
  • Publisher: Transworld Research Network