| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We develop the system which can diagnose a tumor depth using the new nanobubble which is applicable for a diagnosis, treatment of oral cancer. We made 4-Nitroquinoline 1-Oxide-induced tongue cancer rat model. Under ultrasonographic monitoring, elastic needles with a metal core were introduced to mark a deep surgical margin of 5 mm from the deepest tumor invasion front. Surgical resection was carried out using elastic needle as the deepest surgical clearance mark. The resected specimen was immediately immersed in gelatin solution maintaining its original shape and orientation, and refrigerated to solidify. Ultrasonographic observations of the gelatin embedded specimens were performed to confirm the surgical clearance. Immediate surgical clearance of the resected specimens could be easily verified intraoperatively. Further, sonographic marking showed a good correlation with the histological margins.
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