Identification of stem cell in oral squamous cell carcinoma and clarification of the tumor angiogenesis mechanism.

• Project/Area Number: 21792028
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Keio University
• Principal Investigator: MORIKAWA Satoru Keio University, 医学部, 助教 (00424169)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 口腔扁平上皮癌 / CD44 / 口腔癌 / 癌幹細胞 / 細胞表面抗原

Research Abstract

We clarified that the appearance of CD44 was not only a cancer stem cell surface marker but also functionally important in the oral squamous cell carcinoma. Especially, we thought to be useful as the cancer stem cell marker that the expression of variant is related to the metastasis.

Research Products

• [Journal Article] Inhibition of Abcg2 transporter on primitive hematopoietic stem cells by All-trans retinoic acid increases sensitivity to anthracycline. (2010)
  • Author(s): Lawrence Lein, Yasuo Nagai, Yo Mabuchi, Sadafumi Suzuki, Satoru Morikawa, Yumi Matsuzaki.
  • Journal Title: Inflammation and Regeneration 30(2) Pages: 55-62
  • NAID: 10026094290
  • Peer Reviewed
• [Journal Article] Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. (2009)
  • Author(s): Satoru Morikawa, Yo Mabuchi, Yoshiaki Kubota, Yasuo Nagai, Kunimichi Niibe, Emi Hiratsu, Sadafumi Suzuki, Chikako Miyauchi-tiara, Narihito Nagoshi, Takehiko Sunabori, Shigeto Shimmura, Atsushi Miyawaki, Taneaki Nakagawa, Toshio Suda, Hideyuki Okano, Yumi Matsuzaki.
  • Journal Title: J Exp Med 206(11) Pages: 2483-2496
  • Peer Reviewed
• [Journal Article] Development of mesenchymal stem cells partially originate from the neural crest. (2009)
  • Author(s): Satoru Morikawa, Yo Mabuchi, Kunimichi Niibe, Sadafumi Suzuki, Narihito Nagoshi, Takehiko Sunabori, Shigeto Shimmura, Yasuo Nagai, Taneaki Nakagawa, Hideyuki Okano, Yumi Matsuzaki.
  • Journal Title: Biochem Biophys Res Commun 379(4) Pages: 1114-1119
  • NAID: 130004571086
  • Peer Reviewed
• [Journal Article] Prospective isolation and identification of human mesenchymal stem cells by flow cytometry. (2009)
  • Author(s): Yo Mabuchi, Satoru Morikawa Sadafumi Suzuki, Takehiko Sunabori, Hideyuki Okano, Yumi Matsuzaki.
  • Journal Title: Inflammation and Regeneration 29(1) Pages: 73-78
  • NAID: 10024797216
  • Peer Reviewed
• [Journal Article] Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow (2009)
  • Author(s): Satoru Morikawa
  • Journal Title: The Journal of Experimental Medicine 206 Pages: 2483-2496
  • Peer Reviewed
• [Presentation] Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow (2010)
  • Author(s): Satoru Morikawa
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-03-18
• [Presentation] ヒト間葉系幹細胞の予期的分離とClonal解析 (2010)
  • Author(s): 森川暁、新部邦透、深谷千絵、穂坂康朗、中川種昭
  • Organizer: 第53回春季日本歯周病学会学術大会(口頭)
  • Place of Presentation: 盛岡
• [Presentation] Flow cytometric isolation and clonal identification of mesenchymal stem cells in human bone marrow. (2009)
  • Author(s): Yo Mabuchi, Satoru Morikawa, Hideyuki Okano, Yumi Matsuzaki
  • Organizer: International Society for Stem Cell Research (ISSCR), 7^<th> ANNUAL MEETING(ポスター)
  • Place of Presentation: Barcelona
• [Presentation] 間葉系幹細胞の一部は神経堤から発生する (2009)
  • Author(s): 森川暁、深谷千絵、穂坂康朗、中川種昭
  • Organizer: 第52回日本歯周病学会春季学術大会(口頭)
  • Place of Presentation: 岡山
• [Presentation] Isolation and Identification of Mesenchymal Stem Cells in Human Bone Marrow. (2009)
  • Author(s): 馬渕洋、森川暁、岡野栄之、松崎有未
  • Organizer: 第7回幹細胞シンポジウム(ポスター)
  • Place of Presentation: 東京
• [Presentation] Prospective Isolation of Mesenchymal Stem Cells. (2009)
  • Author(s): S.MORIKAWA, C.FUKAYA, T.NAKAGAWA
  • Organizer: 87^<th> General Session and Exhibition of the IADR (International Association for Dental Reseach)(ポスター)
  • Place of Presentation: Miami, Flolida, USA