| Project/Area Number |
21792030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
DHASHI Masaru Showa University, 歯学部, 兼任講師 (40317524)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TATSUHITO Nagumo 昭和大学, 歯学部, 助教 (70555078)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 低酸素 / 癌幹細胞 / ニッチ / 口腔扁平上皮癌 |
|---|
| Research Abstract |
Recent data suggest that a rare subpopulation of cancer cells, termed cancer stem cells (CSCs), is capable of initiating, maintaining, and expanding the growth of tumor. Furthermore, these CSCs are considered a major cause of tumor recurrence after conventional therapy due to their resistance against chemo- and radio-therapeutic modalities. Thus, CSCs represent a critical therapeutic target. Recently, a number of studies have demonstrated that hypoxic tumour microenvironment controls tumour stem cells. In this study, we investigated the induction of dedifferentiation by hypoxic condition in OSCC cell lines.
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