Epigenomic profiling of oral cancer

• Project/Area Number: 21792032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: TOYOSHIMA Takahiko Showa University, 歯学部, 兼任講師 (90338533)
• Co-Investigator(Kenkyū-buntansha): 新谷 悟 昭和大学, 歯学部, 教授 (80294429)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 口腔扁平上皮癌 / エビジェネティック / メチル化 / 網羅的解析 / エピジェネティック

Research Abstract

Oral cancer arises through accumulation of multiple genetic and epigenetic changes, although genes silenced by epigenetic alterations are not fully understood. Here, we performed genome-wide methylation profiles and identify novel therapeutic tagets.

Research Products

• [Journal Article] A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA. (2010)
  • Author(s): Mukudai Y, Kubota S, Eguchi T, Sumiyoshi K, Janune D, Kondo S, Shintani S, Takigawa M.
  • Journal Title: J Cell Biochem. 111(6) Pages: 1607-1618
• [Journal Article] S-1 mediates the inhibition of lymph node metastasis in oral cancer cells. (2009)
  • Author(s): Sato H, Hatori M, Ando Y, Kurihara Y, Takayama S, Shirota T, Tachikawa T, Shintani S.
  • Journal Title: Oncol Rep. 22(4) Pages: 719-724
• [Journal Article] Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G(1) phase cell cycle arrest. (2009)
  • Author(s): Yoshiba S, Ito D, Nagumo T, Shirota T, Hatori M, Shintani S.
  • Journal Title: Oral Oncol. 45(2) Pages: 109-115
• [Journal Article] Inhibition of TGF-beta1 suppresses motility and invasiveness of oral squamous cell carcinoma cell lines via modulation of integrins and down-regulation of matrix-metalloproteinases.
  • Author(s): Takayama S, Hatori M, Kurihara Y, Kinugasa Y, Shirota T, Shintani S.
• [Journal Article] Inhibition of cyclooxygenase-2suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation.
  • Author(s): Kurihara Y, Hatori M, Ando Y, Ito D, Toyoshima T, Tanaka M, Shintani S.
• [Presentation] Epigenomic profiling of oral cancer
  • Organizer: 9ACOMS2010 in Kuala Lumpur
• [Presentation] Epigenomic profiling of oral cancer
  • Organizer: 2010年日本癌学会
• [Remarks] ホームページ等