The study of the BNCT effect using the transferrin conjugate boron carriers on head and neck cancer

• Project/Area Number: 21792042
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Osaka Medical College
• Principal Investigator: ITO Yuichi Osaka Medical College, 医学部, 助教 (10530701)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ホウ素中性子補足療法 / BSH / BNCT / 口腔悪性腫瘍 / ホウ素中性子捕捉療法

Research Abstract

We conducted a study using Liposome to examine the augmentation of the BNCT effect on oral squamous cell carcinoma. When it modified BSH in TF-PEG-liposome, it was confirmed immunohistochemically that the BSH transportation in cells was accomplished surely. It was actually confirmed that TF-PEG-liposome significantly showed a tumor killing effect as compared with BSH when we conducted neutron to cells. The results suggested that TF-PEG-liposome was useful for making BNCT effect increase.

Research Products

• [Journal Article] Delivery of Sodium Borocaptate (BSH)to Oral Cancer by Transferrin-PEGLiposome, for Boron Neutron Capture Therapy (BNCT). (2010)
  • Author(s): Y.KIMURA, M.SHIMAHARA, Y.ITO, Y.ARIYOSHI, T.SHIMAHARA, S.KAWABATA, S.MIYATAKE, S.KASAOKA, K.ONO.
  • Journal Title: Bulletin of the Osaka Medical College 56 Pages: 65-72
  • Peer Reviewed
• [Journal Article] Delivery of Sodium Borocaptate (BSH) to Oral Cancer by Transferrin-PEG-Liposome, for Boron Neutron Capture Therapy(BNCT) (2010)
  • Author(s): Yoshihiro KIMURA, Yuichi ITO
  • Journal Title: Bulletin of the Osaka Medical College Volume: 56(2) Pages: 65-72
  • Peer Reviewed
• [Journal Article] Disposition of TF-PEG-Liposome-BSH in tumor-bearing mice. (2009)
  • Author(s): Y.Ito, Y.Shimahara, Y.Ariyoshi, M.Shimahara, S.Miyatake, S.Kawabata, S.Kasaoka, K.Ono.
  • Journal Title: Applied Radiation and Isotopes 67 Pages: 109-110
  • Peer Reviewed
• [Journal Article] Disposition of TF-PEG-Liposome-BSH in tumor-bearing mice (2009)
  • Author(s): 伊藤雄一
  • Journal Title: Applied Radiation and Isotopes 67 Pages: 109-110
  • Peer Reviewed
• [Journal Article] 口腔扁平上皮癌に対するホウ素中性子捕捉療法のためのホウ素デリバリーシステムに関する研究 (2009)
  • Author(s): 島原武司、伊藤雄一
  • Journal Title: 口腔腫瘍学会雑誌 21 Pages: 346-346
• [Journal Article] 硼素中性子捕捉療法(BNCT)におけるBSH包埋TF-PEG-Liposome の有用性 (2009)
  • Author(s): 木村吉宏、伊藤雄一
  • Journal Title: 口腔外科学会雑誌 55 Pages: 202-202
• [Presentation] 口腔扁平上皮癌細胞に対するホウ素運搬体を用いたBNCT 効果の検討 (2011)
  • Author(s): 伊藤雄一、木村吉宏、有吉靖則、島原政司
  • Organizer: 第29回日本口腔腫瘍学会
  • Place of Presentation: 熊本
  • Year and Date: 2011-01-27
• [Presentation] 口腔扁平上皮癌細胞に対するホウ素運搬体を用いたBNCT効果の検討 (2011)
  • Author(s): 伊藤雄一
  • Organizer: 第29回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 崇城大学市民ホール(熊本市)
• [Presentation] 口腔扁平上皮癌細胞へのホウ素化合物の取り込みと細胞内局在に関する検討 (2010)
  • Author(s): 伊藤雄一、木村吉宏、有吉靖則、島原武司、武井祐子、島原政司
  • Organizer: 第64回日本口腔科学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-24
• [Presentation] BNCT における口腔扁平上皮癌細胞でのホウ素化合物の細胞内局在に関する研究 (2010)
  • Author(s): 伊藤雄一、有吉靖則、木村吉宏、島原武司、武井祐子、島原政司
  • Organizer: 第28回日本口腔腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-28
• [Presentation] BNCTにおける口腔扁平上皮癌細胞でのホウ素化合物の細胞内局在に関する研究 (2010)
  • Author(s): 伊藤雄一
  • Organizer: 第28回日本口腔腫瘍学会
  • Place of Presentation: 学術総合センター(東京)
  • Year and Date: 2010-01-28
• [Presentation] 口腔扁平上皮癌細胞へのホウ素化合物の取り込みと細胞内局在に関する検討 (2010)
  • Author(s): 伊藤雄一
  • Organizer: 第64回日本口腔科学会 学術集会
  • Place of Presentation: 札幌プリンスホテル国際館パミール(札幌)
• [Presentation] 口腔扁平上皮癌細胞への硼素化合物移送に関する研究 (2009)
  • Author(s): 伊藤雄一、木村吉宏、有吉靖則、島原政司、宮武伸一、川端信司、笠岡敏、小野公二
  • Organizer: 第6回日本中性子捕捉療法学会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-19
• [Presentation] 口腔扁平上皮癌細胞への硼素化合物移送に関する研究 (2009)
  • Author(s): 伊藤雄一
  • Organizer: 第6回日本中性子捕捉療法学会
  • Place of Presentation: キャンパスプラザ京都(京都)
  • Year and Date: 2009-09-19
• [Presentation] 再発口腔癌に対する硼素中性子捕捉療法 (2009)
  • Author(s): 木村吉宏、伊藤雄一
  • Organizer: 第6回日本中性子捕捉療法学会
  • Place of Presentation: キャンパスプラザ京都(京都)
  • Year and Date: 2009-09-19