Elucidation of the Mechanism of Odontblast Differentiation by Bone Morphogenetic Factor and Application to Regeneration
Project/Area Number |
21792053
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthodontic/Pediatric dentistry
|
Research Institution | Tohoku University |
Principal Investigator |
MARUYA Yuriko Tohoku University, 大学院・歯学研究科, 助教 (60400389)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 小児歯科学 / 歯髄幹細胞 / GDF-5 / 歯の再生 |
Research Abstract |
Growth/Differentiation Factor-5 (GDF-5) is a member of the bone morphogenetic protein and promotes formation of bones and cartilages. It has been reported that GDF-5 gene is expressed in oral region. However, the roles of GDF-5 in the differentiation of dental pulp cells are unknown. Thus, we investigated the effect of GDF-5 on the differentiation of dental pulp stem cell. GDF-5 promoted production of molecules characteristic for odontoblastic phenotype. These findings suggested that GDF-5 promotes differentiation of dental pulp stem cell to odontblast.
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Report
(3 results)
Research Products
(3 results)