Elucidation of the Mechanism of Odontblast Differentiation by Bone Morphogenetic Factor and Application to Regeneration

Research Project

Project/Area Number	21792053
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Tohoku University
Principal Investigator	MARUYA Yuriko Tohoku University, 大学院・歯学研究科, 助教 (60400389)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	小児歯科学 / 歯髄幹細胞 / GDF-5 / 歯の再生
Research Abstract	Growth/Differentiation Factor-5 (GDF-5) is a member of the bone morphogenetic protein and promotes formation of bones and cartilages. It has been reported that GDF-5 gene is expressed in oral region. However, the roles of GDF-5 in the differentiation of dental pulp cells are unknown. Thus, we investigated the effect of GDF-5 on the differentiation of dental pulp stem cell. GDF-5 promoted production of molecules characteristic for odontoblastic phenotype. These findings suggested that GDF-5 promotes differentiation of dental pulp stem cell to odontblast.

Report

(3 results)