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Pathogenesis of osteoarthritis using response properties of temporomandibular joint mechanoreceptors

Research Project

Project/Area Number 21792061
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FUJITA Kouichi  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 非常勤講師 (30451909)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords変形性関節症 / 咬合干渉 / 顎関節機械受容器 / 電気生理 / ラット / 侵害刺激 / 三叉神経節 / 開口頻度 / 開口強度
Research Abstract

Objective : To investigate pathogenesis of osteoarthritis (OA) and the effects of an experimentally-induced increase in the occlusal vertical dimension (iOVD) on the functional characteristics of temporomandibular joint (TMJ) mechanoreceptors in rats. Materials and methods : Sixty 13-week-old male albino Wistar rats were divided into control and iOVD groups (30 animals each). The vertical dimension between the maxillary and mandibular molars in the iOVD group was increased by 2.0mm with a build-up of resin on the maxillary molars. Single-unit activities of TMJ mechanoreceptors were evoked by passive jaw movement. Recording was performed from the gasserian ganglion at 1 day and 1, 3, 5, 7 and 9 weeks after the establishment of iOVD.
Results : Compared with the control group, the firing threshold was significantly lower at 1, 3 and 5 weeks after iOVD in the iOVD group. There were no significant differences in the firing threshold at 1 day, or 7 or 9 weeks. The Maximum instantaneous firing frequency was significantly higher at 1, 3 and 5 weeks after iOVD in the iOVD group, but there were no significant differences at 1 day, or 7 or 9 weeks. There were no significant differences in the average firing frequency during the experimental period.
Conclusion : The present study findings suggest that TMJ mechanoreceptors in adult rats may adapt to iOVD.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats2011

    • Author(s)
      Naito S, Ishida T, Kokai S, Fujita K、Shibata M、Yabushita T,Ono T
    • Journal Title

      The Angle Orthodontist 81(3)

      Pages: 453-459

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats2011

    • Author(s)
      Naito S, Ishida T, Kokai S, Fujita K, Shibata M, Yabushita T, Ono T
    • Journal Title

      The Angle Orthodontist

      Volume: (in print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 液状飼料飼育が成長期ラットの閉口筋筋紡錘に与える影響2010

    • Author(s)
      柴田真衣
    • Journal Title

      口腔病学会誌 77巻

      Pages: 53-58

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 液状飼料飼育が成長期ラットの閉口筋筋紡錘に与える影響2010

    • Author(s)
      柴田真衣
    • Journal Title

      口腔病学会誌

      Volume: 77 Pages: 53-58

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 咬合高径増加に対するラット顎関節機械受容器の機能適応について2010

    • Author(s)
      内藤聡美、石田宝義、小海暁、藤田紘一、柴田真衣、藪下忠親、小野卓史
    • Organizer
      第75回口腔病学術大会
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 咬合高径増加に対するラット顎関節機械受容器の機能適応について2010

    • Author(s)
      内藤聡美、石田宝義、小海暁、藤田紘一、柴田真衣、藪下忠親, 小野卓史
    • Organizer
      第75回口腔病学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Influence of a liquid diet feeding on jaw-closing muscle spindle in growing rats2010

    • Author(s)
      SHIBATA M., FUJITA K., ISHIDA T., YABUSHITA T.
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of liquid diet feeding after being weaned on the properties of jaw-closing muscle spindles2010

    • Author(s)
      Shibata M, Fujita K, Ishida T, Yabushita T、
    • Organizer
      7th International Orthodontic Congress
    • Related Report
      2010 Final Research Report
  • [Presentation] 状飼料飼育が成長期ラットの顎関節侵害受容器に及ぼす影響について2010

    • Author(s)
      平沼摩耶, 小海暁, 藪下忠親, 小野卓史
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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