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Analyses of pathogenicity of collagen-binding protein of S.mutans for cardiovascular diseases

Research Project

Project/Area Number 21792067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

NOMURA Ryota  Osaka University, 大学院・歯学研究科, 助教 (90437385)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsS.mutans / コラーゲン結合タンパク / 循環器疾患 / 血清型 / Streptococcus mutans / コラーゲン / Cnmタンパク / 脳出血 / 感染性心内膜炎 / 臨床分離株 / Streptococcus aureus / Cbmタンパク / 唾液 / 簡易検出法 / Streptococcus salivarius / 口腔レンサ球菌
Research Abstract

Streptococcus mutans is known as a major pathogen of dental caries and also to cause infective endocarditis. Recently, an approximately 120-kDa Cnm protein with binding properties to type I collagen was identified and we found that Cnm-positive S.mutans strains have a prevalence of approximately 10-20%. Furthermore, Cnm-positive strains were predominantly identified among serotype f and k stains, even though those are considered to be minor serotypes in the oral cavity. Cnm positivity may be an important virulence factor for vascular diseases because of the ability of such strains to bind to exposed collagen tissue.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (45 results)

All 2011 2010 2009 2008

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (24 results)

  • [Journal Article] Isolation and characterization of Streptococcus mitis from blood of child with osteomyelitis.2011

    • Author(s)
      Nomura R, Nakano K, Makela K, Vaara M, Salo E, Alaluusua S, Ooshima T.
    • Journal Title

      Int J Paediatr Dent in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular detection of human periodontal pathogens in oral swab specimens from dogs in Japan.2011

    • Author(s)
      Kato Y, Shirai M, Murakami M, Mizusawa T, Hagimoto A, Wada K, Nomura R, Nakano K, Ooshima T, Asai F.
    • Journal Title

      J Vet Dent in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of aortic aneurysm of cardiovascular diseases patients with P.gingivalis occurrence.2011

    • Author(s)
      Nakano K, Wada K, Nomura R R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Hata H, Toda K, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
    • Journal Title

      Oral Dis in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of Streptococcus mitis from blood of child with osteomyelitis.2011

    • Author(s)
      Nomura R, et al.
    • Journal Title

      International Journal of Paediatric Dentistry

      Volume: 21(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oral streptococci with collagen-binding properties in saliva specimens from mothers and their children.2010

    • Author(s)
      Nomura R, Naka S, Nakano K, Taniguchi N, Matsumoto M, Ooshima T.
    • Journal Title

      Int J Paediatr Dent 20

      Pages: 254-260

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defect of glucosyltransferases reduces platelet aggregation activity of Streptococcus mutans : Analysis of clinical strains isolated from oral cavities.2010

    • Author(s)
      Taniguchi N, Nakano K, Nomura R, Naka S, Kojima A, Matsumoto M, Ooshima T.
    • Journal Title

      Arch Oral Biol 55

      Pages: 410-416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis infection in mice with endothelial damage.2010

    • Author(s)
      Hokamura K, Inaba H, Nakano K, Nomura R, Yoshioka H, Taniguchi K, Ooshima T, Wada K, Amano A, Umemura K.
    • Journal Title

      J Periodontal Res 45

      Pages: 337-344

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of Streptococcus mutans clinical strains with gene encoding collagen-binding adhesin.2010

    • Author(s)
      Nakano K, Nomura R, Taniguchi N, Lapirattanakul J, Kojima A, Naka S, Senawongse P, Srisatjaluk R, Gronroos L, Alaluusua S, Matsumoto M, Ooshima T.
    • Journal Title

      Arch Oral Biol 55

      Pages: 34-39

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-surface structures of novel serotype k Streptococcus mutans strains and correlation to virulence.2010

    • Author(s)
      Nakano K, Nomura R, Matsumoto M, Ooshima T.
    • Journal Title

      J Pharmacol Sci 113

      Pages: 120-125

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oral streptococci with collagen-binding properties in saliva specimens from mothers and their children.2010

    • Author(s)
      Nomura R, et al.
    • Journal Title

      International Journal of Paediatric Dentistry

      Volume: 20 Pages: 254-260

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oral streptococci with collagen-binding properties in saliva specimens from mothers and their children.2010

    • Author(s)
      Nomura R, Naka S, Nakano K, et al.
    • Journal Title

      International Journal of Paediatric Dentistry (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of Streptococcus mutans clinical strains with gene encoding collagen-binding adhesin.2010

    • Author(s)
      Nakano K, Nomura R, Taniguchi N, et al.
    • Journal Title

      Archives of Oral Biology 55

      Pages: 34-39

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of periodontopathic bacterial species in Japanese children with developmental disabilities.2009

    • Author(s)
      Naka S, Yamana A, Nakano K, Okawa R, Fujita K, Kojima A, Nemoto H, Nomura R, Matsumoto M, Ooshima T.
    • Journal Title

      BMC Oral Health 9

      Pages: 24-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content.2009

    • Author(s)
      Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, Nomura R, Kawabata S, Ooshima T, Nakai K, Hattori M, Hamada S, Nakagawa I.
    • Journal Title

      BMC genomics 10

      Pages: 358-358

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical analyses of the gene encoding collagen-binding adhesin of Streptococcus mutans.2009

    • Author(s)
      Nomura R, Nakano K, Tanigichi N, Lapirattanakul J, Nemoto H, Gronroos L, Alaluusua S, Ooshima T.
    • Journal Title

      J Med Microbiol 58

      Pages: 469-475

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial profiles of oral streptococcal and periodontal bacterial species in saliva specimens from Japanese subjects.2009

    • Author(s)
      Miyamoto E, Nakano K, Fujita K, Nomura R, Okawa R, Matsumoto M, Ooshima T.
    • Journal Title

      Arch Oral Biol 54

      Pages: 374-379

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of S100 calcium-binding protein A9 is required for induction of human smooth muscle cell proliferation by a periodontal pathogen.2009

    • Author(s)
      Inaba H, Hokamura K, Nakano K, Nomura R, Katayama K, Nakajima A, Yoshioka H, Taniguchi K, Kamisaki Y, Ooshima T, Umemura K, Murad F, Wada K, Amano A.
    • Journal Title

      FEBS Lett 583

      Pages: 128-134

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of oral bacteria in cardiovascular specimens.2009

    • Author(s)
      Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 64-68

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analyses of bacterial DNA in extirpated heart valves from infective endocarditis patients.2009

    • Author(s)
      Nomura R, Nakano K, Nemoto H, Mukai T, Hata H, Toda K, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 43-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical analyses of gene encoding collagen-binding adhesin of Streptococcus mutans.2009

    • Author(s)
      Nomra R, Nakano K, Tanigichi N, et al.
    • Journal Title

      Journal of Medical Microbiology 58

      Pages: 469-475

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of serotype k Streptococcus mutans in Thai subjects.2008

    • Author(s)
      Lapirattanakul J, Nakano K, Nomura R, Nemoto H, Kojima A, Senawongse P, Srisatjaluk R, Ooshima T.
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 431-433

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Characterization of novel collagen-binding protein of Streptococcus mutans.2011

    • Author(s)
      Nomura R, Nakano K, Ooshima T.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2011-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship of Streptococcus mutans collagen-binding properties with cerebral hemorrhage deterioration.2011

    • Author(s)
      Nakano K, Nomura R, Taniguchi N, Wada K, Ooshima T.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2011-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Prevalence of amoxicillin-resistant Streptococci in dental plaque of young Japanese.2011

    • Author(s)
      Nemoto H, Nakano K, Masuda K, Nomura R, Ooshima T.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2011-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of novel collagen-binding protein of Streptococcus mutans.2011

    • Author(s)
      Nomura, et al.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児デンタルプラーク中に存在するアモキシシリン耐性口腔細菌種の特定2010

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      平成22年度日本小児歯科学会秋季大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 感染性心内膜炎予防に対する歯科医師における意識調査2010

    • Author(s)
      小島あゆち, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      第29回日本小児歯科学会近畿地方会
    • Place of Presentation
      枚方
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Detection of amoxicillin-resistant streptococcal species in dental plaque specimens.2010

    • Author(s)
      Nemoto, Nakano K, Nomura R, Wada K, Ooshima T.
    • Organizer
      88th IADR meeting
    • Place of Presentation
      Barcelona, Spain.
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of Aortic Aneurysm in Patients Harboring Porphyromonas gingivalis2010

    • Author(s)
      Nakano K, Wada K, Nomura R, Inaba H, Amano A, Ooshima T.
    • Organizer
      88th IADR meeting
    • Place of Presentation
      Barcelona, Spain.
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Contribution of collagen-binding adhesin of Streptococcus mutans to cause deterioration of cerebral hemorrhage.2010

    • Author(s)
      Nomura R, Nakano K, Taniguchi N, Wada K, Matsumoto M, Ooshima T.
    • Organizer
      58th ORCA congress
    • Place of Presentation
      Montpellier, France.
    • Year and Date
      2010-07-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Contribution of collagen-binding adhesin of Streptococcus mutans to cause deterioration of cerebral hemorrhage.2010

    • Author(s)
      Nomura, et al.
    • Organizer
      58th ORCA congress
    • Place of Presentation
      Montpellier, France
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児大腿骨骨髄炎患者血液より分離したStreptococcus mitis株の性状の分析2010

    • Author(s)
      野村良太, 仲野和彦, 小島あゆち, 松本道代, 大嶋隆
    • Organizer
      第48回日本小児歯科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス腸炎モデルにおけるStreptococcus mutansの病原性の検討2010

    • Author(s)
      小島あゆち, 仲野和彦, 野村良太, 松本道代, 大嶋隆
    • Organizer
      第48回日本小児歯科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳動脈損傷モデルにおけるStreptococcus mutansコラーゲン結合タンパクの病原性への関与2010

    • Author(s)
      谷口奈穂, 仲野和彦, 野村良太, 松本道代, 大嶋隆
    • Organizer
      第48回日本小児歯科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児大腿骨骨髄炎患者血液より分離したStreptococcus mitis株の性状の分析2010

    • Author(s)
      野村良太, 仲野和彦, 小島あゆち, 松本道代, 大嶋隆
    • Organizer
      第48回日本小児歯科学会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Streptococcus mutans臨床分離株におけるグルコシルトランスフェラーゼの発現と血小板凝集能への関与2009

    • Author(s)
      谷口奈穂, 仲野和彦, 野村良太, 松本道代, 大嶋隆
    • Organizer
      第28回日本小児歯科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児プラーク中に存在するアモキシシリン耐性菌の分布に関する検討2009

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 松本道代, 大嶋隆
    • Organizer
      第28回日本小児歯科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児唾液中に存在するコラーゲン結合能を有する菌株の分析2009

    • Author(s)
      仲周平, 野村良太, 仲野和彦, 大嶋隆
    • Organizer
      第28回日本小児歯科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular analyses of Streptococcus mutans strains with collagen-binding properties.2009

    • Author(s)
      Nomura R, Nakano K, Taniguchi N, Kojima A, Naka S, Ooshima T.
    • Organizer
      56th ORCA congress
    • Place of Presentation
      Budapest, Hungary.
    • Year and Date
      2009-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Presence of serotype k strains of Streptococcus mutans strains is a potential risk factor for cerebral hemorrhage.2009

    • Author(s)
      Nakano K, Taniguchi N, Kojima A, Nomura R, Wada K, Ooshima T.
    • Organizer
      56th ORCA congress
    • Place of Presentation
      Budapest, Hungary.
    • Year and Date
      2009-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular analyses of Streptococcus mutans strains with collagen-binding properties.2009

    • Author(s)
      Nomura R, Nakano K, Taniguchi N, Kojima A, Naka S, Ooshima T.
    • Organizer
      57th Congress of European Organization of Caries Research
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 唾液サンプルにおける口腔レンサ球菌・歯周病原性細菌の分布の検討2009

    • Author(s)
      宮本えり子, 仲野和彦, 野村良太, 松本道代, 大嶋隆
    • Organizer
      第47回日本小児歯科学会
    • Place of Presentation
      吹田
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液中に含まれる口腔レンサ球菌のコラーゲン結合能に関する分析2009

    • Author(s)
      仲周平, 野村良太, 仲野和彦, 大嶋隆
    • Organizer
      第47回日本小児歯科学会
    • Place of Presentation
      吹田
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳動脈損傷モデルにおけるS.mutansの病原性の検討2009

    • Author(s)
      谷口奈穂, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      第47回日本小児歯科学会
    • Place of Presentation
      吹田
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓血管系疾患患者の病変部およびデンタルプラーク検体における口腔細菌種の検出2009

    • Author(s)
      根本浩利, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      第47回日本小児歯科学会
    • Place of Presentation
      吹田
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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