Analyses of pathogenicity of collagen-binding protein of S.mutans for cardiovascular diseases
| Project/Area Number |
21792067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NOMURA Ryota Osaka University, 大学院・歯学研究科, 助教 (90437385)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | S.mutans / コラーゲン結合タンパク / 循環器疾患 / 血清型 / Streptococcus mutans / コラーゲン / Cnmタンパク / 脳出血 / 感染性心内膜炎 / 臨床分離株 / Streptococcus aureus / Cbmタンパク / 唾液 / 簡易検出法 / Streptococcus salivarius / 口腔レンサ球菌 |
|---|
| Research Abstract |
Streptococcus mutans is known as a major pathogen of dental caries and also to cause infective endocarditis. Recently, an approximately 120-kDa Cnm protein with binding properties to type I collagen was identified and we found that Cnm-positive S.mutans strains have a prevalence of approximately 10-20%. Furthermore, Cnm-positive strains were predominantly identified among serotype f and k stains, even though those are considered to be minor serotypes in the oral cavity. Cnm positivity may be an important virulence factor for vascular diseases because of the ability of such strains to bind to exposed collagen tissue.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Characterization of aortic aneurysm of cardiovascular diseases patients with P.gingivalis occurrence.2011
Author(s)
Nakano K, Wada K, Nomura R R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Hata H, Toda K, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Molecular characterization of Streptococcus mutans clinical strains with gene encoding collagen-binding adhesin.2010
Author(s)
Nakano K, Nomura R, Taniguchi N, Lapirattanakul J, Kojima A, Naka S, Senawongse P, Srisatjaluk R, Gronroos L, Alaluusua S, Matsumoto M, Ooshima T.
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Journal Title
Arch Oral Biol 55
Pages: 34-39
Related Report
Peer Reviewed
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[Journal Article] Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content.2009
Author(s)
Maruyama F, Kobata M, Kurokawa K, Nishida K, Sakurai A, Nakano K, Nomura R, Kawabata S, Ooshima T, Nakai K, Hattori M, Hamada S, Nakagawa I.
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Journal Title
BMC genomics 10
Pages: 358-358
Related Report
Peer Reviewed
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[Journal Article] Upregulation of S100 calcium-binding protein A9 is required for induction of human smooth muscle cell proliferation by a periodontal pathogen.2009
Author(s)
Inaba H, Hokamura K, Nakano K, Nomura R, Katayama K, Nakajima A, Yoshioka H, Taniguchi K, Kamisaki Y, Ooshima T, Umemura K, Murad F, Wada K, Amano A.
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Journal Title
FEBS Lett 583
Pages: 128-134
Related Report
Peer Reviewed
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