| Project/Area Number |
21792071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KAWANABE Noriaki Okayama University, 岡山大学病院, 講師 (00397879)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯科矯正学 / ヒト乳歯歯根膜幹細胞 / ヒト乳歯歯髄幹細胞 / Stage-specific embryonic antigen-4 / ヒト乳歯歯髄細胞 |
|---|
| Research Abstract |
In the present study, we investigated if SSEA-4 could serve as a marker to distinguish human deciduous tooth-derived stem cells. Clonal assay demonstrated that 68.4% of SSEA-4-positive periodontal ligament (PDL) cells and 85.7% of SSEA-4-positive dental pulp (DP) cells exhibit either adipogenic or osteogenic potential. In addition, these cells showed adipogenic, osteogenic, and chondrogenic differentiation. These results showed that SSEA-4 can be used to promote the enrichment of stem cells from the PDL and DP of human deciduous teeth.
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