Elucidation of the mechanism of osteoblast differentiation inhibition by LPS derived from A. a.

• Project/Area Number: 21792074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MEIKO Tachikake 広島大学, 病院, 病院助教 (90530775)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 歯周病原性菌 / 小児 / 細胞間ネットワーク / 歯周病原生菌

Research Abstract

Lipopolysaccharide(LPS) derived from A. ggregatibacter actinomycetemcomitans(A. a) suppressed osteoblast differentiation and LPS derived from A. a inhibits osteoblast differentiation through an intercellular network. LPS was a potential inhibitor. Alterations in intracellular Cx43 localization may be involved in intercellular network inhibition.