Central mechanisms of circadian entrainment via oral functions
Project/Area Number |
21792075
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Osaka University |
Principal Investigator |
NAKAMURA Wataru Osaka University, 大学院・歯学研究科, 特任准教授 (60372257)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 体内時計 / 概日リズム / 環境同調 / 時計遺伝子 / 予知行動 / 制限給餌 / 時計遺伝子改変マウス / 時計遺伝子変異マウス |
Research Abstract |
Many animals have an ability to anticipate periodic food availability. In this study, we have examined the food anticipatory activity in circadian clock deficient mice. Some KO mice which have slightly differences in intrinsic circadian period show limited entrainment to various period of feeding ; the other molecular clock deficient mice do not. These results suggest that the canonical molecular clock may not drive food anticipatory behavioral activity, but may control it as a circadian manner.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro.2010
Author(s)
Yagita K, Horie K, Koinuma S, Nakamura W, Yamanaka I, Urasaki A, Shigeyoshi Y, Kawakami K, Shimada S, Takeda J, Uchiyama Y.
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Journal Title
Proc.Natl.Acad.Sci.U.S.A. 107(8)
Pages: 3846-3851
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