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Central mechanisms of circadian entrainment via oral functions

Research Project

Project/Area Number 21792075
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

NAKAMURA Wataru  Osaka University, 大学院・歯学研究科, 特任准教授 (60372257)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords体内時計 / 概日リズム / 環境同調 / 時計遺伝子 / 予知行動 / 制限給餌 / 時計遺伝子改変マウス / 時計遺伝子変異マウス
Research Abstract

Many animals have an ability to anticipate periodic food availability. In this study, we have examined the food anticipatory activity in circadian clock deficient mice. Some KO mice which have slightly differences in intrinsic circadian period show limited entrainment to various period of feeding ; the other molecular clock deficient mice do not. These results suggest that the canonical molecular clock may not drive food anticipatory behavioral activity, but may control it as a circadian manner.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (12 results)

  • [Journal Article] Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes.2010

    • Author(s)
      Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y.
    • Journal Title

      Biochemistry. 49(37)

      Pages: 8053-61

    • Related Report
      2010 Final Research Report
  • [Journal Article] 概日行動リズムを制御する視交叉上核2010

    • Author(s)
      中村渉
    • Journal Title

      時間生物学 16巻

      Pages: 3-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro.2010

    • Author(s)
      Yagita K, Horie K, Koinuma S, Nakamura W, Yamanaka I, Urasaki A, Shigeyoshi Y, Kawakami K, Shimada S, Takeda J, Uchiyama Y.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107(8)

      Pages: 3846-3851

    • Related Report
      2010 Final Research Report
  • [Journal Article] Behavioral analysis of circadian rhythms: Entraining the circadian clock and determining the food-entrainable oscillator mechanism.2010

    • Author(s)
      Nakamura W.
    • Journal Title

      Sleep Biol Rhythms. 8(1)

      Pages: 28-33

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes.2010

    • Author(s)
      Noguchi, T, …, Nakamura W, et al.
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 8053-8061

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 概日行動リズムを制御する視交叉上核2010

    • Author(s)
      中村渉
    • Journal Title

      時間生物学

      Volume: 16 Pages: 3-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro.2010

    • Author(s)
      Yagita K
    • Journal Title

      Proc.Natl.Acad. Sci.U.S.A. 107

      Pages: 3846-3851

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス行動概日リズムの光同調と非光同調2010

    • Author(s)
      中村渉
    • Organizer
      第16回日本光生物学協会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-08-10
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス行動概日リズムの光同調と非光同調2010

    • Author(s)
      中村渉
    • Organizer
      第16回日本光生物学協会年会
    • Place of Presentation
      大阪大学(招待講演)
    • Year and Date
      2010-08-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] The food-entrainable oscillator does not drive anticipatory activity, but controls it as circadian manner.2010

    • Author(s)
      Nakamura W.
    • Organizer
      12th Biennial Meeting of Society for Research on Biological Rhythms.
    • Place of Presentation
      FL (USA)
    • Year and Date
      2010-05-23
    • Related Report
      2010 Final Research Report
  • [Presentation] The food-entrainable oscillator does not drive anticipatory activity, but controls it as circadian manner.2010

    • Author(s)
      Nakamura W.
    • Organizer
      12th Biennial Meeting of Society for Research on Biological Rhythms.
    • Place of Presentation
      FL(USA)フロリダ
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 概日リズムを制御する階層的神経回路構造の解明2010

    • Author(s)
      中村渉
    • Organizer
      第8回口腔医科学フロンティア
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 概日リズムを制御する階層的神経回路構造の解明2010

    • Author(s)
      中村渉
    • Organizer
      第8回口腔医科学フロンテイア
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 概日行動リズムを制御する視交叉上核2009

    • Author(s)
      中村渉
    • Organizer
      日本時間生物学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-27
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Food-entrainment: current controversies and recent progress.2009

    • Author(s)
      Nakamura W.
    • Organizer
      XI. Congress of the European Biological Rhythms Society.
    • Place of Presentation
      フランス・ストラスブール
    • Year and Date
      2009-08-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Food-entrainment : current controversies and recent progress.2009

    • Author(s)
      Nakamura W
    • Organizer
      XI. Congress of the European Biological Rhythms Society.
    • Place of Presentation
      フランス・ストラスブール
    • Year and Date
      2009-08-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Circadian output in the suprachiasmatic nucleus.2009

    • Author(s)
      Nakamura W.
    • Organizer
      XI. Congress of the European Biological Rhythms Society.
    • Place of Presentation
      フランス・ストラスブール
    • Year and Date
      2009-08-26
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Different property of food anticipatory activity in BMAL1-deficient mice.2009

    • Author(s)
      Nakamura W.
    • Organizer
      International Symposium on Biological Rhythm.
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Different property of food anticipatory activity in BMAL1-deficient mice2009

    • Author(s)
      Nakamura W
    • Organizer
      International Symposium on Biological Rhythm
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-04
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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