Abnormality of receptor mechanism and cartilage in transgenic mice with mutant PTH/PTHrP receptor
| Project/Area Number |
21792098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SHIMOMURA Junko The Nippon Dental University, 新潟生命歯学部, 准教授 (00386286)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 骨 / 軟骨 / PTH/PTHrP受容体 / 遺伝子変異 / マウス / PTH / PTHrP受容体 |
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| Research Abstract |
The aim of this study was to elucidate the altered signaling pathway and abnormal cell differentiation caused by the PTH/PTHR receptor with P132L mutation (PTH-R^<P132L>), which is overexpressed in murine cartilage. Transgenic mice carrying PTH-R^<P132L> were generated and histologically analyzed. As a consequence, the histological phenotype of cartilage of PTH-R^<P132L> transgenic mice was similar to the knockout mice of PTHrP or PTH-R.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line2010
Author(s)
Li M, Seki Y, Freitas PH, Nagata M, Kojima T, Sultana S, Ubaidus S, Maeda T, Shimomura J, Henderson JE, Tamura M, Oda K, Liu Z, Guo Y, Suzuki R, Yamamoto T, Takagi R, Amizuka N
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Journal Title
J Electron Microscopy 59
Pages: 227-236
NAID
Related Report
Peer Reviewed
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