| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
The aim of this study was to elucidate the altered signaling pathway and abnormal cell differentiation caused by the PTH/PTHR receptor with P132L mutation (PTH-R^<P132L>), which is overexpressed in murine cartilage. Transgenic mice carrying PTH-R^<P132L> were generated and histologically analyzed. As a consequence, the histological phenotype of cartilage of PTH-R^<P132L> transgenic mice was similar to the knockout mice of PTHrP or PTH-R.
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