Mechanism, prevention, and treatment of the nitrogen-containing bisphosphonate-related osteonecrosis of the jaw.
| Project/Area Number |
21792101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
FUNAYAMA Hiromi Tsurumi University, 歯学部, 助教 (00359530)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビスフォスフォネート / ビスフォスフォート / 顎骨壊死 / マウスモデル |
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| Research Abstract |
Nitrogen-containing bisphosphonates (NBPs) are powerful anti-bone-resorptive drugs, but they induce unexpected new side effect, osteonecrosis of the jaw (ONJ). Few ONJ cases have been reported in patients treated with non-NBPs. A single subcutaneous injection of an NBP into the ear pinna induced tissue IL-1b and IL-18 at the injection site, while non-NBP lacked this effect. LPS augments the NBP-induced inflammatory cytokines, co-administration of non-NBP with NBP abolishes these augmentations.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Promotion of arthritis and allergy in mice by aminoglycoglycerophospholipid, a membrane antigen specific to Mycoplasma fermentans.2010
Author(s)
Sato N, Oizumi T, Kinbara M, Sato T, Funayama H, Sato S, Matsuda K, Takada H, Sugawara S, Endo Y.
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Journal Title
FEMS Immunol Med Microbiol. 59(1)
Pages: 33-41
Related Report
Peer Reviewed
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[Journal Article] Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP) : a proposal for possible utilization of etidronate as a substitution drug for NBPs.2010
Author(s)
Oizumi T, Funayama H, Yamaguchi K, Yokoyama M, Takahashi H, Yamamoto M, Kuroishi T, Kumamoto H, Sasaki K, Kawamura H, Sugawara S, Endo Y.
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Journal Title
J Oral Maxillofac Surg. 68(5)
Pages: 1043-1054
Related Report
Peer Reviewed
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[Journal Article] Promotion of arthritis and allergy in mice by aminoglycoglycerophospholipid, a membrane antigen specific to Mycoplasma fermentans.2010
Author(s)
Sato N, Oizumi T, Kinbara M, Sato T, Funayama H, Sato S, Matsuda K, Takada H, Sugawara S, Endo Y.
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Journal Title
FEMS Immunol Med Microbiol.
Volume: 59
Pages: 33-41
Related Report
Peer Reviewed
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