| Project/Area Number |
21792101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University |
|---|
Principal Investigator |
FUNAYAMA Hiromi Tsurumi University, 歯学部, 助教 (00359530)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビスフォスフォネート / ビスフォスフォート / 顎骨壊死 / マウスモデル |
|---|
| Research Abstract |
Nitrogen-containing bisphosphonates (NBPs) are powerful anti-bone-resorptive drugs, but they induce unexpected new side effect, osteonecrosis of the jaw (ONJ). Few ONJ cases have been reported in patients treated with non-NBPs. A single subcutaneous injection of an NBP into the ear pinna induced tissue IL-1b and IL-18 at the injection site, while non-NBP lacked this effect. LPS augments the NBP-induced inflammatory cytokines, co-administration of non-NBP with NBP abolishes these augmentations.
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