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Identification of am3 gene and an underlying study for establishment of risk diagnostic procedure using SNPs

Research Project

Project/Area Number 21792102
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTsurumi University

Principal Investigator

NARIYAMA Megumi  Tsurumi University, 歯学部, 助教 (90440304)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords分子遺伝学 / 歯の発育異常 / am3遺伝子 / リスク診断 / ELマウス
Research Abstract

The present study attempted to define genes causing an absence of the third molars in EL mice with the majority exhibiting the absence of all third molars. I analyzed the mRNA expressions of candidate genes (Lef1, Egf) in the am3 locus indicated with linkage analysis and other candidate genes (Shh, Pitx2, Bmp2, Bmp4) in the EL and control mice using Real-time PCR. The results of PCR suggest that Lef1, Egf, Bmp2, and Bmp4 are involved in the absence of the third molars in EL mice.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Effect of third molar absence on development of masticatory muscles inEL mice.2010

    • Author(s)
      Megumi Nariyama, Yuki Kota, Itaru Tashima, Tadafumi Tomohiro, Akira Yamane, Yoshinobu Asada
    • Journal Title

      Pediatric Dental Journal Vol.20, No.2

      Pages: 122-129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice.2010

    • Author(s)
      Megumi Nariyama, Yuki Kota, Itaru Tashima, Tadafumi Tomohiro, Akira Yamane, Yoshinobu Asada
    • Journal Title

      Pediatric Dental Journal

      Volume: 20 Pages: 122-129

    • NAID

      10027485798

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of third molar absence on development of masticatory muscles inEL mice.2010

    • Author(s)
      Meeumi Nariyama, Yuki Kota,Itaru Tashima, Tadafumi Tomohiro, Akira Yamane, Yoshiuobu Asada
    • Journal Title

      Pediatric Dental Journal 20巻(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lack of teeth and expression of myosins in masticatory muscles2010

    • Author(s)
      Yamane A, Nariyama M, Kota Y, Asada Y
    • Organizer
      58th annual meeting of JADR
    • Place of Presentation
      Kyushu Dental College, Kitakyushu
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 咬筋の神経筋接合部におけるアセチルコリン受容体クラスター形成2010

    • Author(s)
      森愛美, 成山明具美, 阿保徳寿, 山根明, 朝田芳信
    • Organizer
      平成22年度、一般社団法人日本小児歯科学会秋季大会
    • Place of Presentation
      郡山市民文化センター
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effects of Lack of Occlusal Activity on Masticatory Myogenesis2010

    • Author(s)
      Nariyama M, Kota Y, Yamane A, Tomohiro T, Asada Y
    • Organizer
      88th General Session & Exhibition of the IADR
    • Place of Presentation
      Centre de Convencions Internacional Barcelona
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス第三臼歯欠如が咀嚼筋の発達過程に及ぼす影響2010

    • Author(s)
      成山明具美, 古宇田ゆき, 田島格, 友廣忠文, 山根明, 朝田芳信
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effects of Lack of Occlusal Activity on Masticatory Myogenesis2010

    • Author(s)
      Nariyama M, Kota Y, Yamane A, Tomohiro T, Asada Y
    • Organizer
      88th General Session & Exhibition of the IADR
    • Place of Presentation
      Centre de Convencions Internacional Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当センターの地域障害者歯科医療への役割と来院患者の26年間の変化2009

    • Author(s)
      中島智仁, 山本俊雄, 端山智弘, 伊奈幹晃, 倉本弘樹, 朝生博行, 池村雄介, 荒木信清, 成山明具美, 小平裕恵, 阿倍佳子, 關田俊介
    • Organizer
      第26回 日本障害者歯科学会総会および学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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