| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
In this study, Reveromycin A(RM-A) was administered to compare and evaluate bone turnover and response of the surrounding boney tissue including osteoblasts. The ability of RM-A to control tooth movement was evaluated. Reveromycin A administration in OPG-/-mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained. Moreover, by inhibiting the promoted osteoclastic activity of OPG-/-mice using reveromycin A, excessive osteoblast activity was also inhibited. It is suggested that osteoblast activity was inhibited because some negative factors from osteoclasts to osteoblasts functioned after inhibition of osteoclast activity.
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