A control of tooth movement by pharmacologic agent using the coupling mechanism on bone.
| Project/Area Number |
21792106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯学 / 動物 / 歯科矯正学 / 病理学 / 薬理学 |
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| Research Abstract |
In this study, Reveromycin A(RM-A) was administered to compare and evaluate bone turnover and response of the surrounding boney tissue including osteoblasts. The ability of RM-A to control tooth movement was evaluated. Reveromycin A administration in OPG-/-mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained. Moreover, by inhibiting the promoted osteoclastic activity of OPG-/-mice using reveromycin A, excessive osteoblast activity was also inhibited. It is suggested that osteoblast activity was inhibited because some negative factors from osteoclasts to osteoblasts functioned after inhibition of osteoclast activity.
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Report
(4 results)
Research Products
(3 results)
